Evidence map›Paper›PMID 42779993›Full record

ArticlebioRxiv : the preprint server for biology2026

Pichinde virus models intrauterine infection by hemorrhagic fever-causing arenaviruses.

Craig J Bierle, Hannah Murphy, Jason S Hatfield, Qinfeng Huang, Tyler B Rollman, Priyanka Chauhan, Brigitte Flannery, Sarah A Wernimont, Terry K Morgan, Micah D Gearhart and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Craig J BierleDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota.ORCID 0000-0002-7890-7409
Hannah MurphyDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota.
Jason S HatfieldDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota.
Qinfeng HuangDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota.
Tyler B RollmanDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota.
Priyanka ChauhanDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota.
Brigitte FlanneryDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota.
Sarah A WernimontDepartment of Obstetrics, Gynecology and Women's Health, University of Minnesota.
Terry K MorganDepartment of Pathology, Oregon Health & Science University.
Micah D GearhartDepartment of Obstetrics, Gynecology and Women's Health, University of Minnesota.ORCID 0000-0002-9873-1930
Yuying LiangDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota.
Hinh LyDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
Trophoblast development and placental susceptibility to cytomegalovirus infectionR01HD109252 · NICHD · UNIVERSITY OF MINNESOTA · PI Craig John Bierle · 2022 to 2026
$2.2M
CTSA Predoctoral T32 at University of MinnesotaT32TR004385 · NCATS · UNIVERSITY OF MINNESOTA · PI Jayne Allyn Fulkerson · 2024 to 2026
$1.3M
Immune regulation of arenavirus infections in the placentaR01HD117756 · NICHD · UNIVERSITY OF MINNESOTA · PI Craig John Bierle, YUYING LIANG · 2025 to 2026
$1.3M
NCATS NIH HHS T32 TR004385NCATS NIH HHS UM1 TR004405NICHD NIH HHS R01 HD109252NICHD NIH HHS R01 HD117756
6 · The paper itself

Abstract

Arenavirus infection during pregnancy can cause severe maternal disease, congenital infection, and fetal demise. Many arenaviruses are endemic in economically disadvantaged areas and must be studied in high containment laboratories, which has limited our understanding of arenavirus pathogenesis in the placenta. Pichinde virus (PICV) is a nonpathogenic arenavirus that recapitulates many aspects of viral hemorrhagic fever in guinea pigs. Using a combination of experiments in human placental cells and guinea pigs, we characterized the tropism and impact of PICV infection during pregnancy. PICV replicated in human trophoblast stem cells (TSCs), TSC-derived trophoblasts, and explanted term placenta. When guinea pigs were infected at mid-gestation, PICV caused fetal demise. High infectious titers were recovered from placenta and decidua, but PICV was infrequently detected in fetal tissues or amniotic fluid.

Identifiers

PMID42779993
PMCPMC13596394

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.