ArticleResearch square2026
Age as a biological stratifier for immune checkpoint inhibitor response in ovarian cancer.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: Immune checkpoint inhibitor (ICI) monotherapy produces response rates of only 8-15% in ovarian cancer, widely considered ICI-refractory. However, DNA damage sensing and interferon signaling undergo pronounced age-dependent remodeling, making patient age a plausible modifier of ICI response. Methods: We integrated four ovarian cancer transcriptomic cohorts (n = 761) and tested the age-by-BRCA-immune interaction by pre-specified random-effects meta-analysis, comparing Young (< 50 y) versus Old (≥ 60 y) patients with the peri- and early post-menopausal transition (50-59 y) excluded from primary comparisons. Age-dependent expression of cGAS, STING1, IFI16, and IDO1 was quantified. A single-institution ICI-treated cohort (USC/LAGMC, n = 20; Responder defined as progression-free interval ≥ 365 days) provided clinical anchoring. Results: Patient age reversed the BRCA-immune relationship across all four cohorts (pooled interaction b = -0.275, 95% CI - 0.502 to - 0.048, p = 0.018, I Conclusions: Patient age is a biological determinant of the ovarian cancer immune microenvironment through selective STING1/IFI16 attenuation with cGAS preserved. These findings support a systematic reanalysis of existing ovarian cancer ICI clinical trial data stratified by patient age.
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