Evidence map›Paper›PMID 42779965›Full record

ArticlebioRxiv : the preprint server for biology2026

Split suppression gene drives reveal a design tradeoff between inheritance and reproductive load in

William A C Gendron, Andrea L Smidler, Ming Li, Tyler Wise, Héctor M Sánchez C, Jared B Bennett, Robyn Raban, John M Marshall, Omar S Akbari

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

William A C GendronSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, San Diego, California, 92093, USA.
Andrea L SmidlerSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, San Diego, California, 92093, USA.
Ming LiSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, San Diego, California, 92093, USA.
Tyler WiseSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, San Diego, California, 92093, USA.
Héctor M Sánchez CDivisions of Biostatistics and Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Jared B BennettDivisions of Biostatistics and Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Robyn RabanSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, San Diego, California, 92093, USA.
John M MarshallDivisions of Biostatistics and Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Omar S AkbariSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, San Diego, California, 92093, USA.ORCID 0000-0002-6853-9884

Funding

Close-kin mark-recapture methods to characterize suppression of Aedes aegypti populations resulting from interventions and extreme weather eventsR01AI189916 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI John Macky Marshall · 2026 to 2026
$2.5M
Precision guided SIT for the control of vector-borne diseaseR01AI151004 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKBARI, OMAR SULTAN · 2020 to 2024
$2.3M
Conditional and female lethal approaches for mosquito controlR01AI190001 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Omar Sultan Akbari · 2025 to 2026
$1.2M
NIAID NIH HHS R01 AI151004NIAID NIH HHS R01 AI189916NIAID NIH HHS R01 AI190001
6 · The paper itself

Abstract

Mosquito-borne pathogens cause approximately 700,000 deaths annually, highlighting the need for effective and sustainable vector control strategies. CRISPR-based gene drives offer a potential approach for suppressing disease-vector populations, but autonomous drives may spread beyond intended populations. Split gene drives, in which the Cas9 and guide RNA components are genetically separated, provide an inherently confinable alternative because biased inheritance depends on the co-occurrence of both components. Here, we develop the first split suppression gene drives in

Indexed as

Ae. aegyptiCRISPR-Cas9Population ControlSplit Gene Drive

Identifiers

PMID42779965
PMCPMC13596404

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.