Evidence map›Paper›PMID 42779951›Full record

ArticlebioRxiv : the preprint server for biology2026

An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus in

Jun Huang, Connor J Larmore, Timothy C Davenport, Anna Floyd Averette, Yeseul Choi, Humberto Debat, Purav Gupta, Artem Babaian, Marc D Meneghini, Sheng Sun and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jun HuangDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-4071-0926
Connor J LarmoreDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-5341-7788
Timothy C DavenportDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0009-0005-1043-822X
Anna Floyd AveretteDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-5877-0812
Yeseul ChoiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-9369-902X
Humberto DebatInstituto Nacional de Tecnología Agropecuaria (IPAVE-CIAP-INTA), X5020ICA, Córdoba, Argentina.ORCID 0000-0003-3056-3739
Purav GuptaDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.ORCID 0009-0009-8855-9215
Artem BabaianDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.ORCID 0000-0002-4315-6262
Marc D MeneghiniDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.ORCID 0000-0003-0887-4311
Sheng SunDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-2895-1153
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0001-6369-5995

Funding

Rapid production of SARS-CoV-2 molecular clones using CRISPR-based yeast recombineeringR01AI100272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MADHANI, HITEN D · 2012 to 2025
$11.3M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
The Genetic Basis of Virulence in Cryptococcus NeoformansR01AI133654 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN, Paul Mitaari Magwene · 2017 to 2026
$4.7M
RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesisR01AI170543 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2022 to 2026
$3.6M
Calcineurin signaling cascades governing Cryptococcus virulenceR01AI172451 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2023 to 2026
$2.7M
Transmission electron microscope (TEM)S10OD026776 · OD · DUKE UNIVERSITY · PI MILLER, SARA ELIZABETH · 2019 to 2019
$600k
Investigation of a novel mycovirus and its impacts on the biology and pathogenesis of Cryptococcus neoformansR21AI199262 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2026 to 2026
$242k
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI100272NIAID NIH HHS R01 AI133654NIAID NIH HHS R01 AI170543NIAID NIH HHS R01 AI172451NIAID NIH HHS R21 AI199262NIAID NIH HHS R37 AI039115NIH HHS S10 OD026776
6 · The paper itself

Abstract

RNA interference (RNAi) is a widely conserved genome-defense mechanism that protects eukaryotes against viruses and transposable elements. We previously showed that RNAi loss can lead to hypermutation and antifungal drug resistance in the human fungal pathogen

Indexed as

Biological SciencesGeneticsMycovirusNUMTRNAi

Identifiers

PMID42779951
PMCPMC13596313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.