Evidence map›Paper›PMID 42779950›Full record

ArticleResearch square2026

Hypoxemia Surrounding Enteral Feeds in Preterm Infants Receiving Extended Continuous Positive Airway Pressure.

Rachna Mamidi, Kelvin MacDonald, Sheila Markwardt, Alicia Johnson, Mitzi Donabel Go, Matthew Olson, Kristin Milner, Robert Schelonka, Cindy McEvoy

Registry-linked trialAbstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04295564 (Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04295564 nacompletednot on this map

Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled Trial

TypeinterventionalSponsorCynthia McEvoyRan2020 to 2024Enrolled100ConditionsNeonatal, Premature Birth, Respiratory Distress SyndromeArmsAdditional 2 weeks of CPAP
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachna MamidiUniversity of Missouri.ORCID 0000-0003-0561-0898
Sheila MarkwardtOregon Health & Science University.
Mitzi Donabel GoOregon Health & Science University.ORCID 0000-0001-7098-3223
Matthew Olson
Kristin Milner
Robert SchelonkaOregon Health & Science University.ORCID 0000-0002-2391-920X
Cindy McEvoyOregon Health & Science University.ORCID 0000-0001-8501-8813

Funding

Multidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3M
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled TrialR33HL147906 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCEVOY, CYNTHIA T, TEPPER, ROBERT S. · 2020 to 2023
$2.7M
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled TrialR61HL147906 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCEVOY, CYNTHIA T, TEPPER, ROBERT S. · 2019 to 2019
$657k
NHLBI NIH HHS R33 HL147906NHLBI NIH HHS R61 HL147906NHLBI NIH HHS T32 HL083808
6 · The paper itself

Abstract

Objectives: Hypoxemia is common in preterm infants and associated with morbidities. We evaluated the relationship between OG feeds and hypoxemia and the effect of extending CPAP. Design/Methods: In this prospective substudy of the NHLBI-supported trial (NCT04295564), stable preterm infants were randomized to two additional weeks of CPAP (eCPAP) or CPAP discontinuation (dCPAP) to room air. Oxygen saturation was analyzed before, during, and after feeds in 30 infants. The primary outcome was percent time with SpO Results: Infants randomized to eCPAP spent significantly less time with SpO Conclusions: Extending CPAP reduced hypoxemia in preterm infants. OG feedings were not associated with increased hypoxemia or IH.

Identifiers

PMID42779950
PMCPMC13596651

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.