Evidence map›Paper›PMID 42779942›Full record

ArticlebioRxiv : the preprint server for biology2026

Firewalled synthetic commensal blocks horizontal gene transfer in the gut.

Eric Hu, Kathryn Gorman Durben, Bogdan Budnik, Daniel H Arlow, Sungwhan F Oh, Akos Nyerges

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eric HuDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Kathryn Gorman DurbenGnotobiotic Core Facility, Harvard Medical School, Boston, MA 02115, USA.
Bogdan BudnikWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.ORCID 0000-0003-3622-2003
Daniel H ArlowAnsa Biotechnologies, Inc., Emeryville, CA 94608, USA.
Sungwhan F OhDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0280-7903
Akos NyergesDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1581-490X

Funding

Development of a Gene-Transfer-Resistant and Biocontained Next-Generation Bacterial Host for Controlled Drug DeliveryR00EB035165 · NIBIB · HARVARD MEDICAL SCHOOL · PI Akos Nyerges · 2026 to 2026
$249k
NIBIB NIH HHS R00 EB035165
6 · The paper itself

Abstract

Synthetic biology enables the rational reprogramming of microorganisms into living therapeutics and agents for bioremediation. However, such genetically modified organisms (GMOs) disseminate their synthetic genetic information into natural microbial communities through horizontal gene transfer (HGT), posing biosafety risks that limit clinical and environmental deployment

Identifiers

PMID42779942
PMCPMC13596443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.