Evidence map›Paper›PMID 42779934›Full record

ArticlebioRxiv : the preprint server for biology2026

Bacterial-derived cyclic lipopeptides suppress dauer arrest in

Xiao Wang, Kelsie M Nauta, Marco E Mechan-Llontop, Darrick R Gates, Nirmal Chaudhary, Amudha Ramchandran, Kersten K Sykes, Corrie L Sakowski, Vashnie H Hartwell, Jade Tarango and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiao WangVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.ORCID 0000-0003-3026-2477
Kelsie M NautaVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.ORCID 0000-0002-4715-0634
Marco E Mechan-LlontopVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.ORCID 0000-0001-5644-4768
Darrick R GatesVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Nirmal ChaudharyNatural Products Discovery Core, Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.
Amudha RamchandranNatural Products Discovery Core, Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.
Kersten K SykesVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Corrie L SakowskiVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Vashnie H HartwellVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.ORCID 0009-0004-5016-449X
Jade TarangoVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.
Ashootosh TripathiNatural Products Discovery Core, Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-2297-8088
Nicholas O BurtonVan Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, 49503, USA.

Funding

IDENTIFYING MICROBIAL MECHANISMS THAT REGULATE ANIMAL INSULIN SIGNALINGDP2DK139569 · NIDDK · VAN ANDEL RESEARCH INSTITUTE · PI Nicholas O Burton · 2023 to 2026
$2.9M
NIDDK NIH HHS DP2 DK139569
6 · The paper itself

Abstract

Secondary bacterial metabolites can regulate animal physiology, but the specific bacterial genes and molecules responsible for regulating, synthesizing, and transporting these molecules and the mechanisms by which they impact animal physiology often remain unclear. Here, we used

Indexed as

C. eleganscyclic lipopeptidesdaf-1daf-8dauerinsulin signalingmassetolide FmicrobiomePseudomonas luridaTGF-β

Identifiers

PMID42779934
PMCPMC13596385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.