Evidence map›Paper›PMID 42779868›Full record

ArticlebioRxiv : the preprint server for biology2026

An adenylyl cyclase switch reroutes carbon from growth to virulence lipids in

Selva Rupa Christinal Immanuel, Julie Do, Eliza J R Peterson, Kristopher A Hunt, Amardeep Kaur, Min Pan, Albel Singh, Wei-Ju Wu, Apoorva M Bhatt, Nitin S Baliga

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Selva Rupa Christinal ImmanuelInstitute for Systems Biology, Seattle, WA 98109, USA.ORCID 0000-0002-3642-9605
Julie DoInstitute for Systems Biology, Seattle, WA 98109, USA.
Eliza J R PetersonInstitute for Systems Biology, Seattle, WA 98109, USA.ORCID 0000-0003-2934-5267
Kristopher A HuntInstitute for Systems Biology, Seattle, WA 98109, USA.ORCID 0000-0003-0024-4913
Amardeep KaurInstitute for Systems Biology, Seattle, WA 98109, USA.
Min PanInstitute for Systems Biology, Seattle, WA 98109, USA.
Albel SinghSchool of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.
Wei-Ju WuInstitute for Systems Biology, Seattle, WA 98109, USA.
Apoorva M BhattSchool of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0002-6655-1636
Nitin S BaligaInstitute for Systems Biology, Seattle, WA 98109, USA.ORCID 0000-0001-9157-5974

Funding

Technology CoreU19AI135976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI SHERMAN, DAVID R · 2018 to 2022
$17.0M
A systems analysis of drug tolerance in Mycobacterium tuberculosisR01AI128215 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI Nitin S Baliga · 2017 to 2026
$8.8M
Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National StudyR01AI141953 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2019 to 2023
$5.7M
Bill & Melinda Gates Foundation INV-009322NIAID NIH HHS R01 AI128215NIAID NIH HHS R01 AI141953NIAID NIH HHS U19 AI135976
6 · The paper itself

Abstract

Anti-TB drugs act non-uniformly on

Indexed as

antitubercular drug mechanism of actioncAMP signalingcentral carbon metabolismelectron transport chaingenome-scale metabolic modelingGSK 2556286 (GSK-286)Mycobacterium tuberculosisphthiocerol dimycocerosate (PDIM)Rv1625c (adenylyl cyclase)TBD11 (mCLB073)

Identifiers

PMID42779868
PMCPMC13596540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.