ArticlebioRxiv : the preprint server for biology2026
HNF4A maintains proximal tubule identity and limits injury-associated cell states in the adult mouse kidney.
Fariba Nosrati, Zeinab Dehghani-Ghobadi, Eunah Chung, Christopher Ahn, Hee-Woong Lim, Joo-Seop Park
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Fariba NosratiFeinberg Cardiovascular & Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Zeinab Dehghani-GhobadiFeinberg Cardiovascular & Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Eunah ChungFeinberg Cardiovascular & Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Christopher AhnDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hee-Woong LimDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-8599-1808 Joo-Seop ParkFeinberg Cardiovascular & Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-4190-4386 Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9MThe Role of Renal Interstitium in Kidney DevelopmentR01DK127634 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CARROLL, THOMAS JOSEPH, PARK, JOO-SEOP · 2021 to 2024
$2.8MHox Genes & Lineage InfidelityR01DK120842 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARK, JOO-SEOP · 2019 to 2023
$2.5MHedgehog gene regulatory networks in the mammalian kidneyR01DK131052 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARK, JOO-SEOP · 2022 to 2025
$1.9MRetinoic acid gene regulatory networks in the mammalian kidneyR01DK120847 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARK, JOO-SEOP · 2019 to 2022
$1.7MGene regulatory networks in the proximal tubules of the mammalian kidneyR01DK125577 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARK, JOO-SEOP · 2020 to 2022
$1.4MNCI NIH HHS P30 CA060553NIDDK NIH HHS R01 DK120842NIDDK NIH HHS R01 DK120847NIDDK NIH HHS R01 DK125577NIDDK NIH HHS R01 DK127634NIDDK NIH HHS R01 DK131052
6 · The paper itselfAbstract
Introduction: HNF4A is required for proximal tubule maturation during kidney development, but its role in maintaining proximal tubule identity in the adult kidney has not been defined. Following acute kidney injury, Methods: We conditionally deleted Results: In Conclusions: These findings identify HNF4A as a key regulator of proximal tubule identity and homeostasis in the adult mouse kidney. Genetic loss of
Indexed as
failed-repair proximal tubule cellsHNF4Aimmature proximal tubulekidney injurymaladaptive repairproximal tubule
Identifiers
PMID42779854
PMCPMC13596559
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