Evidence map›Paper›PMID 42779845›Full record

ArticlebioRxiv : the preprint server for biology2026

Synaptic proteomics identifies cathepsin B as a regulator of synapse remodelling during learning.

Aelon Rahmani, Michaela E Johnson, Rosemary A Coleman, Nina Hartman, Anne Poljak, Yee Lian Chew

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aelon RahmaniCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Australia.ORCID 0009-0007-8498-6901
Michaela E JohnsonCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Australia.ORCID 0000-0003-2653-3078
Rosemary A ColemanCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Australia.ORCID 0009-0009-1494-871X
Nina HartmanCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Australia.
Anne PoljakBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Australia.ORCID 0000-0001-9953-1984
Yee Lian ChewCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Australia.ORCID 0000-0001-6078-9312

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Learning requires dynamic changes in synaptic protein composition. Most synaptic proteomic studies capture endpoint snapshots following training, overlooking molecular changes occurring during learning itself. We previously established TurboID proximity proteomics as an approach to capture protein-level changes during learning in the nervous system of

Indexed as

BehaviourCaenorhabditis elegansLearningMemoryProteomicsSynapse

Identifiers

PMID42779845
PMCPMC13596243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.