ArticlebioRxiv : the preprint server for biology2026
Astrocyte-oligodendrocyte crosstalk dependent myelination via secreted protein YKL40.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although oligodendrocyte differentiation and myelin formation are inherent properties of oligodendrocyte progenitor cells (OPCs) that are guided by intrinsic transcriptional and epigenetic programs, this process in the brain is finely regulated by signals coming from other cells, including astrocytes. Here, we identified the astrocyte secreted protein YKL40 at the center of astrocyte-OPC cross-communication and myelination in the developing brain. We find that YKL40 is expressed by astrocytes within white matter areas in the developing brain, coinciding with the OPC differentiation and myelination. Deletion of YKL40 in astrocytes showed delayed developmental myelination and reduced OPC proliferation. Interestingly, coculture with OPCs
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