Evidence map›Paper›PMID 42779800›Full record

ArticlebioRxiv : the preprint server for biology2026

Chemically modified CRISPR enzymes for multi-organ genome editing

Christopher M Baehr, Alzbeta Ressnerova, Min Kang, Sheng Zhao, Beatrice Le, Rania F Haddad, Kunica Asija, Mark Damante, Rohit Sharma, Christy George and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Christopher M BaehrInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0003-2618-1332
Alzbeta RessnerovaInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0002-3021-1525
Min KangInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0009-0003-8665-213X
Sheng ZhaoInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0009-0002-9890-048X
Beatrice LeUniversity of California, Berkeley; Berkeley, CA, USA.ORCID 0009-0005-3354-2759
Rania F HaddadInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.
Kunica AsijaInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0001-7272-0267
Mark DamanteDepartment of Neurological Surgery, The Ohio State University; Columbus, OH, USA.ORCID 0000-0001-9750-6283
Rohit SharmaInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0003-1428-5521
Christy GeorgeInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0002-6273-8081
Heidi HuangInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0009-0008-9626-0507
Dror AssaInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0001-7301-1358
Eric A NoelInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0003-0839-5476
Brigette ManoharInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0009-0004-3803-4035
P Anthony OteroDepartment of Neurological Surgery, The Ohio State University; Columbus, OH, USA.ORCID 0000-0002-1191-6917
Meika TravisDepartment of Neurological Surgery, The Ohio State University; Columbus, OH, USA.ORCID 0000-0001-6724-9925
Kayla SaikalyDepartment of Neurological Surgery, The Ohio State University; Columbus, OH, USA.ORCID 0009-0005-3090-1103
Sophie HuDepartment of Neurological Surgery, The Ohio State University; Columbus, OH, USA.
Victor S Van LaarDepartment of Neurological Surgery, The Ohio State University; Columbus, OH, USA.ORCID 0000-0001-5789-2191
Russell R LonserDepartment of Neurological Surgery, The Ohio State University; Columbus, OH, USA.
John G FlanneryUniversity of California, Berkeley; Berkeley, CA, USA.ORCID 0000-0002-0720-8897
Niren MurthyInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0002-7815-7337
Ross C WilsonInnovative Genomics Institute, University of California Berkeley; Berkeley, CA, USA.ORCID 0000-0002-0644-5540

Funding

Resource Core II: In Vivo CoreU19NS132303 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ross C Wilson · 2023 to 2026
$19.7M
NINDS NIH HHS U19 NS132303
6 · The paper itself

Abstract

Delivery remains the main obstacle to the development of

Identifiers

PMID42779800
PMCPMC13596248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.