Evidence map›Paper›PMID 42779777›Full record

ArticlebioRxiv : the preprint server for biology2026

Cardiomyocyte vulnerability to lamin polymer disruption revealed by saturation mutagenesis.

Jessica Mella, Abigail Hein, Navraj Lally, Julia Conrad, Cathy Yang, Andrew P Landstrom, Vasanth Vedantham, Willow Coyote-Maestas, Abigail Buchwalter

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica MellaCardiovascular Research Institute, University of California, San Francisco, USA.ORCID 0000-0001-7541-6789
Abigail HeinCardiovascular Research Institute, University of California, San Francisco, USA.ORCID 0000-0002-2477-6327
Navraj LallyCardiovascular Research Institute, University of California, San Francisco, USA.ORCID 0009-0004-2233-1318
Julia ConradTetrad Graduate Program, University of California, San Francisco, USA.ORCID 0009-0007-0734-4593
Cathy YangDepartment of Pediatrics, Division of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0009-0008-7398-414X
Andrew P LandstromDepartment of Pediatrics, Division of Cardiology, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1878-9631
Vasanth VedanthamCardiovascular Research Institute, University of California, San Francisco, USA.ORCID 0000-0003-1032-700X
Willow Coyote-MaestasDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, USA.ORCID 0000-0001-9614-5340
Abigail BuchwalterCardiovascular Research Institute, University of California, San Francisco, USA.ORCID 0000-0001-7181-6961

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hundreds of mutations to the broadly expressed

Identifiers

PMID42779777
PMCPMC13596453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.