Evidence map›Paper›PMID 42779762›Full record

ArticlebioRxiv : the preprint server for biology2026

Uncovering a Sex-Specific cAMP Landscape in Vascular Smooth Muscle.

Eric A Pereira da Silva, Ildernandes Vieira-Alves, Hannah Voorhees, Padmini Sirish, Nuria Daghbouche-Rubio, Miguel Martín-Aragón Baudel, Yang K Xiang, Manuel F Navedo, Madeline Nieves-Cintrón

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eric A Pereira da SilvaDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA, 95616, USA.
Ildernandes Vieira-AlvesDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA, 95616, USA.
Hannah VoorheesDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA, 95616, USA.
Padmini SirishDepartment of Internal Medicine, University of California Davis School of Medicine, Davis, CA, 95616, USA.
Nuria Daghbouche-RubioDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA, 95616, USA.
Miguel Martín-Aragón BaudelDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA, 95616, USA.
Yang K XiangDepartment of Medicine and Physiology, University of California Los Angeles School of Medicine, Los Angeles, CA, 90095, USA.
Manuel F NavedoDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA, 95616, USA.ORCID 0000-0001-6864-6594
Madeline Nieves-CintrónDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA, 95616, USA.

Funding

Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Training Program in PharmacologyT32GM144303 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, JOHANNES W HELL · 2022 to 2026
$2.1M
Mechanisms of VSM dysfunction in diabetes and HFpEFR01HL171014 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Manuel F Navedo, Madeline Nieves-Cintron · 2024 to 2026
$2.0M
Pressure Regulation of Vascular CaV1.2 ChannelsR01HL180444 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Manuel F Navedo · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01 HL171014NHLBI NIH HHS R01 HL180444NIGMS NIH HHS T32 GM144303
6 · The paper itself

Abstract

The second messenger, cyclic adenosine monophosphate (cAMP), plays a crucial role in regulating cellular function, including in vascular smooth muscle (VSM). While extensive research has focused on the compartmentalization of cAMP signaling in various cell types, the influence of biological sex on distinct cAMP pools and their functional implications in the VSM remains largely unexplored. To address this knowledge gap, we employed a multiscale experimental approach spanning targeted cAMP biosensors, wire myography, live-cell calcium imaging, proximity ligation assays, and

Indexed as

biosensorscontractilitysignalingvascular functionvasodilation

Identifiers

PMID42779762
PMCPMC13596201

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.