ArticlebioRxiv : the preprint server for biology2026
dubTAGs enable on-demand stabilization for tunable and reversible control of endogenous protein levels.
Sunil Guharajan, Xiangyang Song, Sachi Sengupta, Qiong Wu, Wenyi Wei, Yan Xiong, Jian Jin, Sahin Naqvi
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Sunil GuharajanDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7993-1200 Xiangyang SongMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science, and Neuroscience, The Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0000-0136-3899 Sachi SenguptaDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Qiong WuMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science, and Neuroscience, The Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wenyi WeiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0512-3811 Yan XiongMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science, and Neuroscience, The Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jian JinMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science, and Neuroscience, The Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sahin NaqviDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2635-7967 Funding
Mapping and prediction of quantitative transcription factor dosage effects to understand variation in craniofacial morphology and diseaseR00DE032729 · NIDCR · BOSTON CHILDREN'S HOSPITAL · PI Sahin Naqvi · 2024 to 2026
$747kAn AVANCE NEO 400 MHz NMR Spectrometer for Chemical Biology and Drug DiscoveryS10OD028504 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZHOU, MING-MING · 2020 to 2020
$599kAn AVANCE NEO 600 MHz NMR Spectrometer System for Structural and Chemical BiologyS10OD025132 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZHOU, MING-MING · 2019 to 2019
$535kQuantitative decoding of transcriptional regulation in development and evolutionR35GM165577 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI Sahin Naqvi · 2026 to 2026
$490kNIDCR NIH HHS R00 DE032729NIGMS NIH HHS R35 GM165577NIH HHS S10 OD025132NIH HHS S10 OD028504
6 · The paper itselfAbstract
Precise and rapid control over cellular protein levels is essential to dissect complex biological systems. Chemical genetic approaches such as dTAG, in which a target is fused to a degron tag (FKBP12
Identifiers
PMID42779759
PMCPMC13596203
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