Evidence map›Paper›PMID 42779729›Full record

ArticlebioRxiv : the preprint server for biology2026

Paneth cell-derived Notch ligands DLL1 and DLL4 are crucial for intestinal crypt base stem cells.

Michaela Quintero, Theresa M Keeley, Justin Colacino, Nan Gao, Peter J Dempsey, Linda C Samuelson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michaela QuinteroMolecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-4181-0942
Theresa M KeeleyMolecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Justin ColacinoEnvironmental Health Sciences, University of Michigan, Ann Arbor, MI.
Nan GaoPharmacology, Physiology and Neurosciences, Rutgers Health-New Jersey Medical School, Newark, NJ.
Peter J DempseyPediatrics-Developmental Biology, University of Colorado, Anschutz, CO.
Linda C SamuelsonMolecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-0898-2243

Funding

Mechanisms of Intestinal Stem Cell Injury and RepairR01DK118023 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMUELSON, LINDA C. · 2018 to 2021
$1.7M
Defining the Notch niche for Intestinal Stem cellsF32DK142253 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michaela Katherine Quintero · 2025 to 2026
$155k
NIDDK NIH HHS F32 DK142253NIDDK NIH HHS R01 DK118023
6 · The paper itself

Abstract

Notch signaling is essential for maintaining intestinal stem cell activity and directing epithelial cell fate. Paneth cells have been proposed to be niche cells, providing Notch signal to neighboring stem cells through expression of the key Notch ligands DLL1 and DLL4. However, intestinal stem cells persist in the absence of Paneth cells. Here, we used genetic mouse models to clarify the role of Paneth cell-derived Notch ligands for stem cell function. Paneth cell-specific deletion of

Indexed as

cellular plasticityintestinal regenerationintestinal stem cellNotch signaling

Identifiers

PMID42779729
PMCPMC13596329

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.