Evidence map›Paper›PMID 42779725›Full record

ArticlebioRxiv : the preprint server for biology2026

Specific host translation perturbations promote Tn

Liang Bao, Todd Kitten, Ping Xu

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Liang BaoDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0002-0228-6124
Todd KittenDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0001-6097-7583
Ping XuDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0002-8368-801X

Funding

Oral Streptococcal Fitness And Virulence genesR01DE030121 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI KITTEN, TODD O., XU, PING · 2021 to 2025
$2.5M
Characterization of a conserved streptococcal membrane protein affecting manganese utilizationR21DE034103 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI TODD O. KITTEN, Akira Karasawa · 2025 to 2026
$488k
Comparative Experimental Evolution of Gene Essentiality in Streptococcus sanguinis and S. mutansR03DE034511 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BAO, LIANG · 2025 to 2025
$311k
NIDCR NIH HHS R01 DE030121NIDCR NIH HHS R03 DE034511NIDCR NIH HHS R21 DE034103
6 · The paper itself

Abstract

Integrative and conjugative elements (ICEs) are major drivers of horizontal gene transfer and bacterial genome evolution. Although ICE-encoded regulatory circuits have been extensively characterized, the impact of host physiology on the stability of integrated ICEs remains poorly understood. Here, we identify a host-dependent pathway that links specific host translation perturbations to loss of the ICE Tn

Identifiers

PMID42779725
PMCPMC13596343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.