Evidence map›Paper›PMID 42779659›Full record

ArticlebioRxiv : the preprint server for biology2026

ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways.

James S Ye, Elena Purlyte, Victor A Lopez, Jericha Mill, Lexus Tatge, Thomas Kizzar, Dominique Baldwin, Edrees Rashan, Juhee Kim, David J Pagliarini and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

James S YeDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Elena PurlyteDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Victor A LopezDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jericha MillDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Lexus TatgeDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Thomas KizzarDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Dominique BaldwinDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Edrees RashanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Juhee KimDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
David J PagliariniDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA.ORCID 0000-0002-0001-0087
Diana R TomchickDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Krzysztof PawłowskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Peter M DouglasDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Judith SimcoxDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-7350-6342
Vincent S TagliabracciDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9735-4678

Funding

Biology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9M
Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
Breathing life into dead enzymesDP2GM137419 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI TAGLIABRACCI, VINCENT SCOTT · 2019 to 2020
$2.6M
Discovery and characterization of a novel acylcarnitine transporter in brown adipocytesR01DK133479 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Judith Anne Simcox · 2022 to 2026
$1.5M
Defining the roles of ACAD10/11 in hydroxy lipid catabolism and metabolic diseaseR01DK137976 · NIDDK · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2024 to 2026
$1.2M
Discovering catalytic activities for pseudoenzymesR35GM158265 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Vincent Scott Tagliabracci · 2025 to 2026
$1.1M
NIA NIH HHS T32 AG000213NIDDK NIH HHS R01 DK133479NIDDK NIH HHS R01 DK137976NIGMS NIH HHS DP2 GM137419NIGMS NIH HHS R35 GM158265NIGMS NIH HHS T32 GM135066
6 · The paper itself

Abstract

Ether lipids play critical roles in membrane dynamics, antioxidant defense, and signaling. They comprise ~20% of mammalian phospholipids, and disruptions in their metabolism cause severe genetic disorders and are associated with neurodegenerative and metabolic diseases. Ether lipids are synthesized

Identifiers

PMID42779659
PMCPMC13596139

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.