Evidence map›Paper›PMID 42779627›Full record

ArticlebioRxiv : the preprint server for biology2026

Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role for

Chad A Brunswick, Annie G Defina, Trinity A Wood, Aswathy Sebastian, Alexandria R McKenna, Shoko Murakami, Pu-Hsun Chiu, Shannon M Jordan, Gretchen C Pifer, Istvan Albert and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chad A BrunswickDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.ORCID 0000-0002-7848-5541
Annie G DefinaDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Trinity A WoodDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Aswathy SebastianThe Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA 16802.
Alexandria R McKennaDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Shoko MurakamiDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Pu-Hsun ChiuDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Shannon M JordanDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Gretchen C PiferDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Istvan AlbertThe Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA 16802.
Janine L KwapisDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.ORCID 0000-0002-2349-8601

Funding

Diurnal control of memory allocation by the circadian gene Per1R01AG074041 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI JANINE LYNN KWAPIS · 2022 to 2026
$1.5M
The role of HDAC3 in age-related impairments in memory updatingR21AG068444 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI KWAPIS, JANINE LYNN · 2020 to 2020
$430k
Epigenetic and cellular mechanisms of age-related memory updating impairmentsF31AG087533 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI BRUNSWICK, CHAD ARTHUR · 2024 to 2025
$75k
NIA NIH HHS F31 AG087533NIA NIH HHS R01 AG074041NIA NIH HHS R21 AG068444
6 · The paper itself

Abstract

Existing memories can be updated with new information through a process known as reconsolidation, though the molecular mechanisms underlying this process are poorly understood. Additionally, memory updating is impaired with aging, but little is known about how this impairment occurs. Here, we used a hippocampus-dependent memory updating task alongside transcriptomics to identify which genes are upregulated in the dorsal hippocampus specifically during a memory update in both young adult mice, which show successful memory updating, and in old mice, which do not. In young mice, we observed that distinct transcriptional programs were activated by reconsolidation-dependent memory updating and memory retrieval without new information. In old mice, similar transcriptional programs were engaged by both memory updating and memory retrieval. From our sequencing results, we identified

Identifiers

PMID42779627
PMCPMC13596181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.