Evidence map›Paper›PMID 42779604›Full record

ArticlebioRxiv : the preprint server for biology2026

Discrete synaptic states and context-modulated readouts support continual learning.

Yuan Gao, Stefan Mihalas, Denis Turcu

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuan GaoAllen Institute, Seattle, WA, USA.ORCID 0009-0005-7850-7658
Stefan MihalasAllen Institute, Seattle, WA, USA.ORCID 0000-0002-2629-7100
Denis TurcuAllen Institute, Seattle, WA, USA.ORCID 0000-0002-2955-2568

Funding

Modeling the structure-function relation in a reconstructed cortical tissueR01EB029813 · NIBIB · ALLEN INSTITUTE · PI ARKHIPOV, ANTON, MIHALAS, STEFAN · 2020 to 2020
$1.3M
From diverse dynamics to diverse computation via neural cell typesRF1DA055669 · NIDA · ALLEN INSTITUTE · PI MIHALAS, STEFAN, SHEA-BROWN, ERIC TODD · 2021 to 2021
$1.1M
NIBIB NIH HHS R01 EB029813NIDA NIH HHS RF1 DA055669
6 · The paper itself

Abstract

Biological neural systems learn new behaviors while retaining earlier ones, whereas sequentially trained artificial networks often overwrite parameters and forget previously learned behaviors. We introduce the Context-modulated Synaptic-states Recurrent Neural Network (CoSyn-RNN), a new continual-learning model inspired by heterogeneous synaptic states and neuro-modulatory control. CoSyn-RNN combines sparse recurrent allocation with a discrete protection rule: after each task, recurrent neurons whose synaptic weights cross a fixed threshold form a task-specific neuron group, and their associated parameters enter a protected state during later learning. A neuron-specific gain and a task-cued mask over a fixed base readout control how recurrent activity contributes to behavior. Across various task sequences consisting of many cognitive tasks, training and validation losses and accuracies were maintained throughout learning. The protection rule produced modular, task-ordered recurrent structure compatible with forward reuse of earlier computations. Pairwise recruitment measurements further defined minimum- and maximum-cost curricula that produced markedly different final recurrent structures and different remaining capacity for future learning. Thus, CoSyn-RNN provides a biologically inspired model in which protected synaptic states, sparse allocation, and context-dependent modulation support continual learning.

Indexed as

continual learningneuromodulationrecurrent neural networkssparse allocationsynaptic consolidationsynaptic states

Identifiers

PMID42779604
PMCPMC13596205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.