Evidence map›Paper›PMID 42779583›Full record

ArticlebioRxiv : the preprint server for biology2026

Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRH

Caitlin M Goodpaster, Zachary Zeidler, Michael W Gongwer, Charles J Bland, Meelan Shari, Cassandra B Klune, Nico S Jones, Makayla Ramirez, Maryam-Batul Alturki, Rio Hundley and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Caitlin M GoodpasterDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2456-9010
Zachary ZeidlerDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6539-4360
Michael W GongwerDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4506-1224
Charles J BlandDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Meelan ShariDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0009-0008-2386-5572
Cassandra B KluneDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nico S JonesDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Makayla RamirezDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Maryam-Batul AlturkiDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Rio HundleyDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jolie UtterDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Laura A DeNardoDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-7607-4773

Funding

Prefrontal circuits underlying the maturation of learned avoidanceR01MH127214 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Laura Anne DeNardo · 2022 to 2026
$2.3M
Investigating the effects of early life adversity on the developmental trajectory of avoidance circuitryF31MH138135 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOODPASTER, CAITLIN · 2024 to 2025
$89k
Investigating circuit-specific effects of high-frequency repetitive transcranial magnetic stimulationF30MH134633 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GONGWER, MICHAEL W. · 2023 to 2024
$81k
NIMH NIH HHS F30 MH134633NIMH NIH HHS F31 MH138135NIMH NIH HHS R01 MH127214
6 · The paper itself

Abstract

Early life adversity (ELA) has lasting impacts on emotion circuit function

Identifiers

PMID42779583
PMCPMC13596144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.