ArticleGeriatrics & gerontology international2026
Simple Bedside Muscle-Related Indicators Improve the Identification of Reduced Kidney Function in Hospitalized Older Adults: A Multicenter Cross-Sectional Study.
Article in Geriatrics & gerontology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimCreatinine-based estimated glomerular filtration rate (eGFRcr) may overestimate kidney function in older adults with reduced muscle mass. Although current guidelines recommend cystatin C when creatinine-based estimates are unreliable, its routine use remains limited. We evaluated whether incorporating simple bedside muscle-related indicators into eGFRcr improves the identification of reduced kidney function defined by cystatin C-based estimated glomerular filtration rate (eGFRcys).
methodsWe conducted a multicenter cross-sectional study of hospitalized adults aged ≥ 60 years at four Japanese community hospitals. Three models were evaluated: eGFRcr only (Basic model), eGFRcr plus calf circumference (Model 1), and eGFRcr plus the finger-ring test (Model 2). The primary outcome was continuous eGFRcys, and eGFRcys < 45 mL/min/1.73 m
resultsAmong 98 participants (median age 79 years), adding muscle-related indicators modestly improved model performance. Adjusted R
conclusionIncorporating simple bedside muscle-related indicators to creatinine-based assessment improved the identification of reduced kidney function defined by eGFRcys in hospitalized older adults. These measures may complement eGFRcr interpretation when cystatin C measurement is unavailable or delayed. External validation is required before clinical implementation.
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