Observational studyNeurogastroenterology and motility2026
Abdominal Pain Sensitization Connected With Upper but Not Lower Abdominal Pain in Adults With Gastroparesis.
Observational study in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01696747 (GpR 2), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
GpR 2: Continuation of the NIDDK Gastroparesis Registry for the Characterization and Clinical Course of Gastroparesis Patients
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0 citing papers in PubMed.
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Authors and funding
17 authors.
Funding
Abstract
introductionAlthough pain is recognized as an important symptom in gastroparesis, it has not been well studied and characterized. Quantitative sensory testing (QST) is a psychophysical method that has the potential to provide a measure of pain processing, as well as insight into pain pathophysiology and the prediction of response to specific therapies. We aimed to characterize somatic QST in a well-characterized cohort of patients with gastroparesis.
methodsAdults with scintigraphically defined gastroparesis underwent abdominal QST with assessment of mechanical pain: pain sensitivity (thresholds and tolerance) and pain facilitation (temporal summation). The Patient Assessment of Upper GI Symptoms (PAGI-SYM) upper and lower abdominal pain scales were used.
resultsQST was performed on 264 participants (87% female; age = 18-78 years). In both the upper and lower abdomen, smaller pain thresholds and lower pain tolerance were significantly associated with greater PAGI-SYM upper abdominal pain severity (b's = 0.07-0.15; p's = 0.007-0.02), but not lower abdominal pain severity. Scores on the PAGI-SYM upper and lower abdominal pain scales were moderately correlated (r = 0.48, p < 0.0001). No significant associations were found for temporal summation.
conclusionsOur findings suggest self-reported upper abdominal pain severity correlated with both lower and upper abdominal mechanical pain sensitivity-possibly reflecting secondary sensitization of the abdominal wall, due to viscerosomatic convergence in upper abdominal somatic segments. Lower abdominal pain severity association with only upper (but not lower) abdominal QST may be due to cross-organ sensitization. Further investigations are needed to test the clinical utility of abdominal QST in gastric sensorimotor disorders.
trial registrationClinicalTrials.gov: NCT01696747.
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