Evidence map›Paper›PMID 42779197›Full record

Observational studyDiabetes, obesity & metabolism2026

Evaluating the Effectiveness of the Reducing Weight With Intensive Dietary Support (REWIND) Programme on Type 2 Diabetes Remission.

Ben Griffiths, Salma Mehar, Marta Blangiardo, Alex Bottle, Shivani Misra, Daniel Morganstein, Tony Willis, Edward Gregg

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ben GriffithsImperial College London, School of Public Health, London, UK.ORCID https://orcid.org/0009-0004-8642-0280
Salma MeharNHS North West London Collaboration of Clinical Commissioning Groups, London, UK.
Marta BlangiardoImperial College London, School of Public Health, London, UK.
Alex BottleImperial College London, School of Public Health, London, UK.
Shivani MisraDivision of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Daniel MorgansteinDepartment of Endocrinology, Chelsea and Westminster NHS Foundation Trust, London, UK.
Tony WillisNHS North West London Collaboration of Clinical Commissioning Groups, London, UK.
Edward GreggImperial College London, School of Public Health, London, UK.

Funding

NIHR Applied Research Collaboration North West LondonRoyal Society Wolfson Fellowship
6 · The paper itself

Abstract

aimTo evaluate the real-world effectiveness of the Reducing Weight With Intensive Dietary Support (REWIND) programme, offering total diet replacement or low carbohydrate diet pathways, on weight loss, glycaemic control, glucose-lowering medication prescribing and remission of Type 2 diabetes. MATERIALS AND

methodsWe conducted an observational, pre-post quasi-experimental analysis using primary care electronic health records from North West London. REWIND participants with ≥ 12 months of follow-up (n = 1051) were compared with eligible individuals who were not referred to the programme (n = 66 376). Inverse probability weighting was used to adjust for baseline group differences and outcomes estimated as average treatment effects on the treated.

resultsAt 12 months, REWIND participation was associated with greater weight loss (-2.1 kg [95% CI: -2.7 to -1.5]), reduced glucose-lowering medication prescribing (-12.2% [-13.1 to -11.3]) and increased remission (+4.2% [3.9-4.5]) compared with controls, but no significant difference in glycaemic control. The increase in remission was greater among participants following the total diet replacement pathway (+6.9% [6.1-6.8]) than the low-carbohydrate pathway (+2.9% [2.6-3.2]). Programme completers experienced greater improvements across outcomes, including an +8.1% (7.8%, 8.5%) increase in remission compared with controls.

conclusionsParticipation in REWIND was associated with modest improvements in weight, medication use and diabetes remission compared with usual care. Greater improvements among programme completers suggest that sustaining engagement is an important challenge in achieving benefits from similar programmes in routine care.

Indexed as

Diabetes Mellitus, Type 2Diet, ReducingObesityWeight LossWeight Reduction ProgramsAgedBlood GlucoseDiet, Carbohydrate-RestrictedFemaleGlycated HemoglobinGlycemic ControlHumansHypoglycemic AgentsLondonMaleMiddle AgedBlood GlucoseGlycated HemoglobinHypoglycemic Agentsdietary interventioneffectivenessprimary carereal‐world evidenceType 2 diabetes

Identifiers

PMID42779197
PMCPMC13731013

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.