ArticleJournal of clinical laboratory analysis2026
Association of IFN-γ +874 T/A Polymorphism With COVID-19 Susceptibility, Severity, and Inflammatory Response: A Case-Control Study From Southern Iran.
Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSignificant interpatient variability in Coronavirus Disease 2019 (COVID-19) manifestations highlights the influence of host genetic factors on disease outcomes. This study examines its association with COVID-19 susceptibility, severity, and inflammatory markers in an Iranian population.
methodsA retrospective case-control analysis was performed on 210 COVID-19 patients and 210 age- and sex-matched control subjects to evaluate whether the Interferon-gamma (IFN-γ) gene polymorphism (+874 T/A) is associated with disease severity.
resultsPatients had more comorbidities (e.g., diabetes 26.2% vs. 14.3%; hypertension 29.5% vs. 16.7%) and pronounced paraclinical abnormalities, including elevated Neutrophil-to-Lymphocyte Ratio (NLR) (8.1 vs. 1.9), C-reactive protein (CRP) (45.5 vs. 3.2 mg/L), and lymphopenia (1.1 vs. 2.1 × 10
conclusionThe IFN-γ +874 TA genotype was independently associated with severe COVID-19. The TA genotype appears to confer increased risk of severe disease, whereas the AA genotype may be linked to a milder clinical presentation despite elevated inflammatory markers. Integration of genetic and hematological parameters may enhance risk stratification; however, further validation in larger and diverse populations is warranted.
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