Evidence map›Paper›PMID 42778983›Full record

ArticleThe Pediatric infectious disease journal2026

Evaluating Risk of Tuberculosis Infection and Disease Among Adolescents Who Are HIV-exposed Uninfected in Botswana.

Melanie M Dubois, Mackenzie Powell, Sara Schenkel, Samuel Kgole, Gosego Masasa, Martha Ngwaca, Boitshepo Phale, Nyaladzi C Maphorisa, Terence Mohammed, Sikhulile Moyo and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pediatric infectious disease journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Melanie M DuboisFrom the Division of Pediatric Infectious Diseases, Weill Cornell Medicine, New York City, New York.ORCID 0000-0001-9972-8533
Mackenzie PowellDepartment of Public Health Sciences, School of Medicine, Queen's University, Kingston, Ontario, Canada.
Sara SchenkelDepartment of Pediatric Global Health, Massachusetts General Hospital, Boston, Massachusetts.
Samuel KgoleBotswana Harvard Health Partnership, Gaborone, Botswana.
Gosego MasasaBotswana Harvard Health Partnership, Gaborone, Botswana.
Martha NgwacaBotswana Harvard Health Partnership, Gaborone, Botswana.
Boitshepo PhaleBotswana Harvard Health Partnership, Gaborone, Botswana.
Nyaladzi C MaphorisaBotswana Harvard Health Partnership, Gaborone, Botswana.
Terence MohammedBotswana Harvard Health Partnership, Gaborone, Botswana.
Sikhulile MoyoBotswana Harvard Health Partnership, Gaborone, Botswana.
Tuduetso MolefiNational TB Program, Ministry of Health, Gaborone, Botswana.
Topo MakhondoNational TB Program, Ministry of Health, Gaborone, Botswana.
Lebalang MosianeNational TB Program, Ministry of Health, Gaborone, Botswana.
Sidney O KololoNational TB Program, Ministry of Health, Gaborone, Botswana.
Tanvi SharmaDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts.
Heather JaspanDivision of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Leslie A EnaneThe Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana.
Lisa M ButlerDepartment of Public Health Sciences, School of Medicine, Queen's University, Kingston, Ontario, Canada.
Lucy MupfumiBotswana Harvard Health Partnership, Gaborone, Botswana.
Paul ChristosDepartment of Population Health Sciences.
Radhika SundararajanCenter for Global Health, Weill Cornell Medicine, New York City, New York.
Jyoti MathadCenter for Global Health, Weill Cornell Medicine, New York City, New York.
Daniel FitzgeraldCenter for Global Health, Weill Cornell Medicine, New York City, New York.
Kathleen PowisBotswana Harvard Health Partnership, Gaborone, Botswana.

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
FLOURISH - Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescent who are HIV Exposed UninfectedR33HD103099 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI JAO, JENNIFER, MAKHEMA, JOSEPH MOEKETSI · 2022 to 2024
$2.5M
Post-Tuberculosis Lung Disease in Youth with and without HIV GloballyR01AI184174 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI Leslie Anne Enane · 2025 to 2026
$2.1M
FLOURISH - Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescent who are HIV Exposed UninfectedR61HD103099 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI JAO, JENNIFER, MAKHEMA, JOSEPH MOEKETSI · 2020 to 2021
$841k
Viral Diversity an Innovative Biomarker for Refining Estimates of HIV IncidenceK43TW012350 · FIC · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI Sikhulile Moyo · 2022 to 2026
$682k
FIC NIH HHS K43 TW012350NCATS NIH HHS UL1 TR002384NIAID NIH HHS R01 AI184174NICHD NIH HHS R33 HD103099NICHD NIH HHS R61 HD103099
6 · The paper itself

Abstract

This Botswana-based study evaluated the prevalence of tuberculosis (TB) infection and disease among 50 adolescents, including 25 HIV-exposed uninfected (HEU) and 25 HIV-unexposed uninfected. We found that 12% of adolescents HEU had a positive QuantiFERON-TB Gold Plus test, while no adolescent HIV-unexposed uninfected tested positive. This exploratory study found that adolescents HEU may be at increased risk for TB infection and disease, with larger studies needed.

Indexed as

adolescentsHIV-exposed uninfectedtuberculosis

Identifiers

PMID42778983
PMCPMC13614518

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.