Evidence map›Paper›PMID 42778961›Full record

ArticleTropical medicine and health2026

Enteropathogen-specific pathways linking moderate-to-severe diarrhea to linear growth faltering in sub-Saharan African children: a decomposition analysis of the GEMS study.

Joseph O Ashaolu, Dar-Der Ji, Titilope A Adesuyi, Isaac A Ajakaiye, Esther A Omoyajowo, Adeola D Adeniran, Sylvain Y M Some

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph O AshaoluInstitute for Global Health Innovations, Duy Tan University, Da Nang, 550000, Vietnam.
Dar-Der JiInternational Health Programme, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan, ROC.
Titilope A AdesuyiDepartment of Cell Biology and Genetics, Faculty of Life Sciences, University of Lagos, Akoka, Lagos, Nigeria.
Isaac A AjakaiyeDepartment of Microbiology, Faculty of Science, University of Ibadan, Ibadan, Nigeria.
Esther A OmoyajowoDepartment of Biochemistry, Dominion University, Ibadan, Nigeria.
Adeola D AdeniranFaculty of Life and Health Sciences, Ulster University, Coleraine, UK.
Sylvain Y M SomeCentre de Recherche en Santé de Nouna (CrSN), Nouna, Burkina Faso. sylvinsome@yahoo.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssociations exist between moderate-to-severe diarrhea (MSD) and growth faltering in children; however, the underlying mechanisms are not well-understood. We evaluated the extent to which seven enteropathogens explain the association between MSD and linear growth faltering in children from sub-Saharan Africa.

methodsWe conducted a pathway decomposition analysis using data from 20,695 children from the Global Enteric Multicenter Study (GEMS), with 8,382 MSD cases and 12,313 controls. Seven pathogens were assessed as possible explanatory variables for the MSD-growth association.

resultsTwo pathogens significantly explained the MSD-growth association: ETEC (27.0%, p<0.001) and Cryptosporidium (42.8%, p<0.001). Shigella (71.7%, p=0.063) and Adenovirus (80.5%, p=0.067) showed potential but imprecise effects. Rotavirus did not explain linear growth (28.2%, p=0.243) but strongly explained weight-related outcomes (WAZ: 119.1%; WHZ: 79.7%).

conclusionThe MSD-growth association was explained by ETEC and Cryptosporidium. Rotavirus explained weight-related outcomes but not linear growth. Growth benefits associated with rotavirus vaccination may operate through prevention of acute wasting rather than stunting.

Indexed as

Child growthEnteropathogensEnvironmental enteropathyGEMSModerate-to-severe diarrheaPathway decomposition analysisRotavirusStuntingSub-Saharan Africa

Identifiers

PMID42778961
PMCPMC13602548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.