Evidence map›Paper›PMID 42778860›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2027

Two-Step Lipase-Catalyzed Acylation of Non-Glycosylated Flavonoids: Application to Phloretin.

Jose L Gonzalez-Alfonso, David Rodriguez-Garcia, Carlos Uceda-Dominguez, Antonio O Ballesteros, Francisco J Plou

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Article in Methods in molecular biology (Clifton, N.J.), 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jose L Gonzalez-AlfonsoInstitute of Catalysis and Petrochemistry (ICP-CSIC), Marie Curie 2, 28049, Madrid, Spain. josel.g@csic.es.ORCID http://orcid.org/0000-0002-3396-7985
David Rodriguez-GarciaInstitute of Catalysis and Petrochemistry (ICP-CSIC), Marie Curie 2, 28049, Madrid, Spain. davidr@csic.es.ORCID http://orcid.org/0009-0008-6709-3914
Carlos Uceda-DominguezInstitute of Catalysis and Petrochemistry (ICP-CSIC), Marie Curie 2, 28049, Madrid, Spain. carlos.uceda.dominguez.6@csic.es.
Antonio O BallesterosInstitute of Catalysis and Petrochemistry (ICP-CSIC), Marie Curie 2, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-1967-2056
Francisco J PlouInstitute of Catalysis and Petrochemistry (ICP-CSIC), Marie Curie 2, 28049, Madrid, Spain. fplou@icp.csic.es.ORCID http://orcid.org/0000-0003-0831-893X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe an efficient method for acylating non-glycosylated polyphenols, which involves an initial α-glucosylation step catalyzed by sucrose phosphorylase, followed by acylation using an immobilized lipase. This method is applied to phloretin. It is first glucosylated at the 4'-OH position, followed by quantitative acylation at the 6-OH of glucose with C8, C12, and C16 acyl chains using the lipase from Thermomyces lanuginosus. The aqueous solubility of the acyl glucosides is similar to that of the aglycone. The radical scavenging capacity of the new phloretin derivatives measured with ABTS

Indexed as

FlavonoidsLipasePhloretinAcylationEnzymes, ImmobilizedGlucosyltransferasesGlycosylationEnzymes, ImmobilizedFlavonoidsGlucosyltransferasesLipasePhloretinsucrose phosphorylaseAcylationAntioxidantsDihydrochalconesFlavonoidsLipasesPolyphenols

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What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.