ArticleAAPS PharmSciTech2026
Modeling Bioactive Release from Cyclodextrin Complex-Loaded Polymeric Films: A Unified Theoretical Framework Integrating Host-Guest Thermodynamics, Partitioning, and Multi-Mechanism Transport.
Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bioactive release from polymeric films loaded with cyclodextrin (CD) inclusion complexes couples host-guest equilibrium to multi-species transport. This work establishes the Cyclodextrin-Polymer Film Interactive Release (CPFIR) model, integrating complexation thermodynamics with diffusion, swelling, and erosion. Its central element is the Thermodynamic Eigenrate Decomposition (TED), which reduces each mechanism to a first-order depletion rate in s
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