Evidence map›Paper›PMID 42778781›Full record

SynthesisSurgical endoscopy2026

Efficacy and safety of Braun enteroenterostomy in patients undergoing pancreatoduodenectomy: a systematic review and meta-analysis.

Marios Alogakos, Ahmed Ghani, Stefan Bitar, Georgia Angeliniades, Konstantinos Manousidis, May Y Hajeir, Lamees M Al Darwashi, Christian A Than, Hayato Nakanishi, Alexandra M Roch and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marios AlogakosDepartment of Surgery, Division of Surgical Oncology, Indiana University School of Medicine, 545 Barnhill Dr, EH541, Indianapolis, IN, 46202, USA.
Ahmed GhaniSchool of Medicine, University College Dublin, Dublin, D04 C1P1, Ireland.
Stefan BitarSchool of Medicine, University of Nicosia, 2417, Nicosia, Cyprus.
Georgia AngeliniadesSchool of Medicine, University of Nicosia, 2417, Nicosia, Cyprus.
Konstantinos ManousidisSchool of Medicine, University of Nicosia, 2417, Nicosia, Cyprus.
May Y HajeirSchool of Medicine, University of Nicosia, 2417, Nicosia, Cyprus.
Lamees M Al DarwashiSchool of Medicine, University of Nicosia, 2417, Nicosia, Cyprus.
Christian A ThanCambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 OQQ, England.
Hayato NakanishiDepartment of Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Alexandra M RochDepartment of Surgery, Division of Surgical Oncology, Indiana University School of Medicine, 545 Barnhill Dr, EH541, Indianapolis, IN, 46202, USA.
Eugene P CeppaDepartment of Surgery, Division of Surgical Oncology, Indiana University School of Medicine, 545 Barnhill Dr, EH541, Indianapolis, IN, 46202, USA. eceppa@iu.edu.ORCID http://orcid.org/0000-0002-8368-2232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy (PD). Braun enteroenterostomy (BEE) has been proposed as an adjunct to reduce DGE. This meta-analysis aims to evaluate the safety and efficacy of BEE in patients undergoing PD.

methodsCINAHL, PubMed, Embase, Scopus, Web of Science, and Cochrane were searched from inception until November 2025. The pooled mean and proportions were analyzed using a random-effects model. This review was prospectively registered with PROSPERO (CRD420251160291).

resultsSeventeen studies comprising 2731 patients were included, consisting of 1407 (51.5%) patients with BEE and 1324 (48.5%) without BEE. Serious morbidity was similar between groups (OR = 0.66, 95% CI 0.36, 1.19, I

conclusionsBEE appears to be a safe and effective adjunct in selected adult patients undergoing PD. Despite a higher operative time, BEE was associated with a decreased rate of DGE and POPF. However, these findings were not confirmed in a subgroup analysis of four RCTs and should therefore be interpreted with caution. Further randomized prospective studies are required to assess the causative effect of BEE and confirm these promising findings.

Indexed as

EnterostomyGastroparesisLaparoscopyPancreaticoduodenectomyPostoperative ComplicationsHumansReoperationTreatment OutcomeBraun enteroenterostomyDelayed gastric emptyingMeta-analysisPancreatoduodenectomyPostoperative pancreatic fistula

Identifiers

PMID42778781
PMCPMC13633350

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.