ArticleNature medicine2026
Persistence of mucosal CAR-T cells and inflammatory remodeling in enterocolitis associated with BCMA CAR-T cell therapy.
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Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
54 authors.
Nikhit Kethidi *Department of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1417-201X
Saumya Pothukuchi *Department of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0003-8190-2670
Adolfo AlemanDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8884-2100
Daniel CharytonowiczDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christina KuhnDepartment of Medical Bioinformatics, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
Thomas WongDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0005-8616-7833
Jennifer ClaytorJill Roberts Center for Inflammatory Bowel Disease, Weill Cornell Medicine New York Presbyterian, New York, NY, USA.
Pablo Canales-HerreriasDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Samane KhoshbakhtPopulation Health Science and Policy, Center for Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-3253-7577
Akanksha AcharyaDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0002-4866-9427
Michael TankelevichDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tin Htwe ThinDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7891-1459
Divya JhaDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5038-241X
Matthias CeulemansDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-9951-5383
Alexandra E LivanosDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8418-3400
Catherine Le BerreDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zachary M AviganDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-1208-9260
Luise FischerDepartment of Hematology, Hemostaseology, and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0009-0006-3619-2958
Jacqueline E Birkness-GartmanDepartment of Pathology, Division of Gastrointestinal and Liver Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Joanna MeliaDepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yimei JinDepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rachel ChenHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Isha ParikhHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Meenakshi MehrotraDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Erika PatelDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.
Shriya DesaiDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sidorela ReciDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kedwin VenturaDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rudra Prasad DuttaDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9794-0151
Benjamin GordonDepartment of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine New York Presbyterian, New York, NY, USA.
Rachel BrodyDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9280-517X
Charlotte Cunningham-RundlesPrecision Immunology Institute and Colton Center for Autoimmunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0725-0320
Zhihong ChenPrecision Immunology Institute and Colton Center for Autoimmunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-7403-7015
Seunghee Kim-SchulzePrecision Immunology Institute and Colton Center for Autoimmunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0192-4400
Parambir S DulaiDivision of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9514-2321
Shruti NaikPrecision Immunology Institute and Colton Center for Autoimmunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-2216-5135
Jane HouldsworthDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6781-1700
Maximilian MerzMemorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2805-5973
Randy S LongmanJill Roberts Center for Inflammatory Bowel Disease, Weill Cornell Medicine New York Presbyterian, New York, NY, USA.
Ivan ZanoniDivision of Immunology, Harvard Medical School and Boston Children's Hospital, Division of Gastroenterology, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3423-7474
Jeremiah FaithPrecision Immunology Institute and Colton Center for Autoimmunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-2691-4500
Jean-Frederic ColombelDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6472-249X
Britta SiegmundMed. Klinik für Gastroenterologie, Infektiologie und Rheumatologie, and Cluster of Excellence ImmunoPreCept, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-0055-958X
Raja AtreyaDepartment of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.ORCID http://orcid.org/0000-0002-8556-8433
Markus F NeurathDepartment of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.ORCID http://orcid.org/0000-0003-4344-1474
Shambavi RichardDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0274-4292
Sundar JagannathDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-2934-6518
Jerome C MartinLaboratoire d'Immunologie, Centre d'Immunomonitorage, CHU Nantes, Nantes Université, Nantes Atlantique, Nantes, France.ORCID http://orcid.org/0000-0003-0068-8776
Eric MeffreDepartment of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
Mayte Suarez-FarinasPopulation Health Science and Policy, Center for Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8712-3553
David Muniz PedrogoDepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexandros D PolydoridesDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8604-0756
Samir ParekhDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9694-8469
Saurabh MehandruDepartment of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. saurabh.mehandru@mssm.edu.ORCID http://orcid.org/0000-0001-9781-2969
Funding
No grant is acknowledged in the PubMed record.
Abstract
B cell-targeted therapies are expanding across oncologic and autoimmune indications, yet their consequences for mucosal immunity remain incompletely examined. Here we define the pathophysiology of ciltacabtagene autoleucel chimeric antigen receptor (CAR)-T cell-induced enterocolitis (EC) (CAR-T
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42778764What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.