Divergent ring opening and functionalization of N-alkyl aziridines via boryl radical fragmentation.

Pan Peng, Baptiste Roure, Thomas Lulli, Chiara Stavagna, Giovanni Lonardi, Daniele Leonori

Abstract read

In one paragraph

Article in Nature chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pan PengInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.

Baptiste RoureInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0002-6459-8094

Thomas LulliInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0009-0002-4836-0219

Chiara StavagnaInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0009-0000-4546-7841

Giovanni LonardiInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0009-0000-0132-9885

Daniele LeonoriInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany. daniele.leonori@rwth-aachen.de.ORCID http://orcid.org/0000-0002-7692-4504

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101086901EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 101150093EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 101150159

6 · The paper itself

Abstract

Aziridine ring opening is a powerful platform for molecular diversification. Unactivated N-alkyl aziridines have long resisted ring opening and cross-coupling, so the installation and removal of N-activating groups followed by N-alkylation remains the most applicable route for aziridine diversification. Here we report a general radical activation mode that directly engages N-alkyl aziridines in ring-opening and divergent functionalization. Coordination of BH

Identifiers

PMID42778750

DOI10.1038/s41557-026-02247-x

PMCPMC13623657

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.