Evidence map›Paper›PMID 42778697›Full record

ArticleNature2026

Single-nucleus transcriptome-wide association study of human brain disorders.

Sanan Venkatesh, Roman Kosoy, Zhenyi Wu, Marios Anyfantakis, Christian Dillard, Prashant N M, David Burstein, Deepika Mathur, Chris Chatzinakos, Bukola Ajanaku and 23 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. GROMTools: scalable individual-level GReX imputation for mega-biobank-scale cohorts.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Sanan VenkateshDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Roman Kosoy *Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhenyi Wu *Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marios AnyfantakisDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christian DillardDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Prashant N MDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-3548-5637
David BursteinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Deepika MathurDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chris ChatzinakosDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Bukola AjanakuDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fotis TsetsosDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Biao ZengDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sonali GuptaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0008-9578-1677
Rachel BercovitchDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0003-4446-8422
Aram HongDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Clara CaseyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marcela AlviaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhiping ShaoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stathis ArgyriouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Karen TherrienDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
PsychAD Consortium
Tim BigdeliDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0003-2215-5946
Pavan AuluckHuman Brain Collection Core, National Institute of Mental Health-Intramural Research Program, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4799-7904
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Stefano MarencoHuman Brain Collection Core, National Institute of Mental Health-Intramural Research Program, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2488-2365
Vahram HaroutunianDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5860-2512
Kiran GirdharDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5622-042X
Jaroslav BendlDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9989-2720
Donghoon LeeDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0453-6059
John F FullardDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9874-2907
Gabriel E HoffmanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Georgios VoloudakisDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.ORCID http://orcid.org/0000-0002-5729-632X
Panos RoussosDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.ORCID http://orcid.org/0000-0002-4640-6239

Funding

Identifying genetically driven gene dysregulation in Alzheimer's disease and related dementias using statistical data integrationR01AG078657 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Georgios Voloudakis · 2023 to 2026
$2.7M
Characterizing and targeting subphenotypes of schizophrenia and bipolar disorder via individually imputed tissue and cell-type specific transcriptomesK08MH122911 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VOLOUDAKIS, GEORGIOS · 2020 to 2023
$770k
NIA NIH HHS R01 AG078657NIMH NIH HHS K08 MH122911
6 · The paper itself

Abstract

Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging

Indexed as

Brain DiseasesCell NucleusGenome-Wide Association StudySingle-Cell Gene Expression AnalysisDorsolateral Prefrontal CortexFemaleGenetic Predisposition to DiseaseHumansMalePrefrontal Cortex

Identifiers

PMID42778697
PMCPMC13600940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.