Evidence map›Paper›PMID 42778691›Full record

ArticleMolecular neurobiology2026

CircBRWD1 Drives Atherosclerotic Plaque Progression by Modulating Macrophage Inflammatory Responses Through miR-141-5p/HMGB1/NF-κB Signaling.

Cheng Wen, Zhi Fang, Yushuang Ruan, Houying Mu, Zikang Dong, Enxiang Tao, Yuanpeng Xia

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cheng Wen *Department of Neurology, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518033, China.
Zhi Fang *Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yushuang Ruan *Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Houying MuDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zikang DongDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Enxiang TaoDepartment of Neurology, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518033, China. taoex@mail.sysu.edu.cn.
Yuanpeng XiaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. xiayuanpeng@hust.edu.cn.ORCID https://orcid.org/0000-0002-9625-2127

Funding

National Natural Science Foundation of China 82201473National Natural Science Foundation of China 82271357National Natural Science Foundation of China 82271454
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory vascular disease. Circular RNAs (circRNAs) have emerged as important regulators of inflammatory processes, but their roles and regulatory mechanisms in atherosclerosis remain incompletely understood. This study aimed to investigate the role of circBRWD1 in atherosclerosis and its involvement in macrophage inflammatory responses. The expression and cellular localization of circBRWD1 were examined in high fat diet (HFD)-fed Apolipoprotein E knockout (ApoE

Indexed as

Disease ProgressionHMGB1 ProteinInflammationMacrophagesMicroRNAsNF-kappa BPlaque, AtheroscleroticRNA, CircularSignal TransductionAnimalsApolipoproteins EMaleMiceMice, Inbred C57BLMice, Knockout, ApoERAW 264.7 CellsApolipoproteins EHMGB1 ProteinMicroRNAsNF-kappa BRNA, CircularAtherosclerosisCircBRWD1CircRNAHMGB1InflammationMacrophageMiR-141-5p

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.