Evidence map›Paper›PMID 42778686›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Universal newborn screening for G6PD deficiency and severe hyperbilirubinemia at a tertiary center in Jerusalem.

Aviad Schnapp, Ohad Neufeld, Sinan Abu-Leil, Rawan Abu Omar, Haneen Azzam, Noa Ofek Shlomai, Smadar Eventov Friedman

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aviad Schnapp *Division of Pediatrics, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. aviadsch@hadassah.org.il.ORCID http://orcid.org/0000-0002-2127-3177
Ohad Neufeld *Division of Pediatrics, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Sinan Abu-LeilDivision of Neonatology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Rawan Abu OmarDivision of Neonatology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Haneen AzzamDivision of Neonatology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Noa Ofek ShlomaiDivision of Neonatology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0001-5004-2397
Smadar Eventov FriedmanDivision of Neonatology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveGlucose-6-phosphate dehydrogenase (G6PD) deficiency is a major risk factor for neonatal hyperbilirubinemia, yet screening protocols are limited to at-risk populations and may miss affected infants. STUDY

designWe reviewed 5413 neonates born at a tertiary center in Jerusalem. Of 4867 with valid results, 81 (1.66%, 2.9% of males) had severe (<2 IU/g Hb) and 108 (2.2%, 4.4% of females) had intermediate enzyme activity (2-10 IU/g Hb). A nested case-control analysis compared newborns with diminished G6PD activity with randomly selected controls.

resultSevere deficiency increased phototherapy risk (OR 4.78; 95% CI 2.60-8.78; p < 0.001). 43.2% of deficient newborns would not have been tested by targeted screening based on family history or ethnicity. Universal screening identified 6.4% of phototherapy-treated neonates who would not have been flagged for treatment under targeted screening.

conclusionUniversal G6PD screening objectively identifies newborns at increased risk for hyperbilirubinemia requiring phototherapy and may support earlier risk-adapted management.

Identifiers

PMID42778686

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