ArticleNature plants2026
SNI1/NSE5 is a cold-sensitive brake on class II crossovers in Arabidopsis.
Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Temperature reshapes meiotic recombination, but how environmental cues alter crossover pathway choice remains unclear. Here, using interval assays, genome-wide crossover maps, genetic mapping of recombination modifiers and targeted genetics, we show that cold shifts crossovers towards subtelomeric regions and increases class II pathway output. Genetic mapping identified a major temperature-responsive locus on chromosome 4, resolved to a 15.6-kb interval containing SNI1, the Arabidopsis NSE5 orthologue and a component of the SMC5/6 complex. Reduced SNI1 function alters the temperature response of meiotic recombination, promoting a subtelomere-biased crossover landscape. Cytology in zip4 mutants shows that SNI1 limits class II crossover formation at 21 °C and that cold weakens this constraint. SNI1 also promotes longer synaptonemal complexes at 21 °C, although total SC length does not by itself predict crossover output. Our data identify SNI1/NSE5 as a temperature-sensitive brake on class II crossovers.
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Registered trials
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