Evidence map›Paper›PMID 42778610›Full record

ArticleNature2026

TRAM promotes Toll-like-receptor-free myddosome signal transduction.

Daniel Fisch, Vaani Ohri, Eleni Anastasakou, Lucia J Wesemann, Joon H Choi, Katherine E Lindblad, Jonathan C Kagan

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel FischDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. daniel.fisch@gimm.pt.ORCID http://orcid.org/0000-0002-8155-0367
Vaani OhriDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3344-855X
Eleni AnastasakouDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0606-3382
Lucia J WesemannDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0003-3660-0841
Joon H ChoiDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4254-0286
Katherine E LindbladDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Jonathan C KaganDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. jonathan.kagan@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-2364-2746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the Toll-like receptor (TLR) signal transduction pathways, activated receptors are present for mere minutes within the initial, membrane-proximal signalling complexes called proto-myddosomes

Identifiers

PMID42778610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.