Evidence map›Paper›PMID 42778609›Full record

ArticleNature2026

The gene-regulatory evolution of the human skeleton.

Yizhi Yan, Nadav Mishol, Katharina Lange, Zicong Zhang, Gal Bodek, Aya Kigel, Noam Priel, Nachshon Egyes, Omer Ronen, Itamar Nini and 25 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Glypican-3-targeted bioconjugates for hepatocellular carcinoma: design, engineering, and translational applications.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Yizhi Yan *Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.
Nadav Mishol *Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Katharina LangeDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Zicong ZhangInstitute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-1444-5054
Gal BodekDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Aya KigelDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Noam PrielDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Nachshon EgyesDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-2619-3002
Omer RonenDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Itamar NiniDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Liat RotenstreichDepartment of Anatomy, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Amit PhilosophDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Sira MartinezEuropean Molecular Biology Laboratory (EMBL Barcelona), Barcelona Biomedical Research Park, Barcelona, Spain.
Silvia BeltramoneInstitute of Evolutionary Biology (UPF-CSIC) and Centre for Genomic Regulation (CRG), Barcelona Biomedical Research Park, Barcelona, Spain.
Rika TsujikawaInstitute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.
Adi RozenblattDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Lucas Esteban WangeInstitute of Evolutionary Biology (UPF-CSIC) and Centre for Genomic Regulation (CRG), Barcelona Biomedical Research Park, Barcelona, Spain.ORCID http://orcid.org/0000-0002-3275-9156
María TorralvoInstitute of Evolutionary Biology (UPF-CSIC) and Centre for Genomic Regulation (CRG), Barcelona Biomedical Research Park, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2267-1406
Guy HirshDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Yael ElboimDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Sergey ViukovDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Idan KorenfeldDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Mythili Damal KandadaiDepartment of Development and Regeneration, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0009-0001-3834-0065
Océane CluzeauDepartment of Development and Regeneration, KU Leuven, Leuven, Belgium.
Malka Nissim-RafiniaDepartment of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
Eran MeshorerDepartment of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0003-4777-986X
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0003-2042-9974
Evie VereeckeDepartment of Development and Regeneration, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-1312-9124
Assaf MaromDepartment of Anatomy, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.ORCID http://orcid.org/0000-0003-0537-4661
Martin KuhlwilmDepartment of Evolutionary Anthropology, University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-0115-1797
Guillaume BourqueInstitute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-3933-9656
Tomas Marques-BonetInstitute of Evolutionary Biology (UPF-CSIC) and Centre for Genomic Regulation (CRG), Barcelona Biomedical Research Park, Barcelona, Spain.ORCID http://orcid.org/0000-0002-5597-3075
Simon FishilevichDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Fumitaka InoueInstitute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan. inoue.fumitaka.7a@kyoto-u.ac.jp.ORCID http://orcid.org/0000-0003-0657-434X
David GokhmanDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. david.gokhman@weizmann.ac.il.ORCID http://orcid.org/0000-0002-3536-9006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal modifications were central to human evolution, enabling adaptations for bipedalism, large cranial vaults and childbirth

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.