Evidence map›Paper›PMID 42778591›Full record

ArticleNature2026

Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila.

Jun Wang, Zixin Cai, Jiaojiao Gu, Shiqi Xiong, Jianhan Yi, Meng Yang, Kexin Chang, Xinrui Ning, Yilin Wen, Yan Yan and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jun Wang *Hunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China.
Zixin Cai *Hunan Research Center of the Basic Discipline for Cell Signaling, College of Biology, Hunan University, Changsha, China.
Jiaojiao GuHunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China.
Shiqi XiongHunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China.
Jianhan YiHunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China.
Meng YangHunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China.ORCID http://orcid.org/0000-0002-2148-9947
Kexin ChangHunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China.
Xinrui NingHunan Research Center of the Basic Discipline for Cell Signaling, College of Biology, Hunan University, Changsha, China.
Yilin WenHunan Research Center of the Basic Discipline for Cell Signaling, College of Biology, Hunan University, Changsha, China.
Yan YanDivision of Life Science, Hong Kong University of Science and Technology, Hong Kong, China.
Jiongming LuShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China. jmlu@sinh.ac.cn.ORCID http://orcid.org/0000-0002-8879-4938
Yirong WangHunan Research Center of the Basic Discipline for Cell Signaling, College of Biology, Hunan University, Changsha, China. wangyirong@hnu.edu.cn.ORCID http://orcid.org/0000-0002-1995-2728
Zongzhao ZhaiHunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China. zongzhao.zhai@foxmail.com.ORCID http://orcid.org/0000-0003-3987-7742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes that are crucial for physiological homeostasis and ageing

Indexed as

Drosophila melanogasterDrosophila ProteinsLongevityMechanistic Target of Rapamycin Complex 1Protein BiosynthesisRNA 5' Terminal Oligopyrimidine SequenceRNA, MessengerAnimalsFeedback, PhysiologicalFemaleMaleMultiprotein ComplexesTOR Serine-Threonine KinasesTranscription FactorsDrosophila ProteinsMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesRNA, MessengerTORC1 protein complex, DrosophilaTOR Serine-Threonine KinasesTranscription Factors

Identifiers

PMID42778591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.