Evidence map›Paper›PMID 42778557›Full record

ArticleNature communications2026

Molecular determinants of species-specific gamete adhesion triggering HAP2-mediated membrane fusion.

Jennifer F Pinello, Andrés Ferriño-Iriarte, Hibba Hussain, Meenakshi Tanwar, Sijil Puthur Vijayan, Tingting Guo, Pierre Legrand, Sujan Manikumar, Ruhama Demissie, Félix A Rey and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jennifer F Pinello *Department of Molecular Biology, University of Wyoming, Laramie, WY, USA. jpinello@uwyo.edu.ORCID http://orcid.org/0000-0002-0115-4656
Andrés Ferriño-Iriarte *Institut Pasteur, Université Paris Cité, CNRS UMR3569, Structural Virology Unit, Paris, France.ORCID http://orcid.org/0000-0003-0821-556X
Hibba HussainDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.
Meenakshi TanwarDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-8759-1151
Sijil Puthur VijayanDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0003-1268-6460
Tingting GuoDepartment of Molecular Biology, University of Wyoming, Laramie, WY, USA.
Pierre LegrandSynchrotron SOLEIL, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0003-2431-2255
Sujan ManikumarDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0009-0005-4012-5275
Ruhama DemissieDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0009-0007-5427-8656
Félix A ReyInstitut Pasteur, Université Paris Cité, CNRS UMR3569, Structural Virology Unit, Paris, France. felix.rey@pasteur.fr.ORCID http://orcid.org/0000-0002-9953-7988
William J SnellDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA. wsnell1@umd.edu.ORCID http://orcid.org/0000-0002-1659-6211
Eduard BaqueroInstitut Pasteur, Université Paris Cité, Nanoimaging Core Facility, Center for Technological Resources and Research, Paris, France. ebaquero@pasteur.fr.ORCID http://orcid.org/0000-0002-4701-4181

Funding

Conserved mechanisms of ciliary signaling and cell-cell fusionR01GM146162 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI William J Snell · 2022 to 2026
$2.8M
Leica Stellaris 8 Confocal for Imaging CoreS10OD034260 · OD · UNIV OF MARYLAND, COLLEGE PARK · PI BEAVEN, AMY · 2023 to 2023
$600k
Membrane proteins driving a cell-cell fusion reaction during fertilizationR00GM146112 · NIGMS · UNIVERSITY OF WYOMING · PI Jennifer Fricke Pinello · 2025 to 2026
$498k
NIGMS NIH HHS R00 GM146112NIGMS NIH HHS R01 GM146162NIH HHS S10 OD034260U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) K99/R00GM146112U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM146162U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) 1S10ODO34260
6 · The paper itself

Abstract

Species-specific adhesion of gametes is a prerequisite to cell fusion during fertilization, yet the underlying molecular mechanisms are not fully understood for any organism. In Chlamydomonas, the adhesion protein MAR1 chaperones the conserved fusogen HAP2 into a pre-fusion conformation on the mt- gamete and is the receptor for the adhesion protein FUS1 on the mt+ gamete. Here, we report the X-ray structure of the FUS1/MAR1 adhesion complex, showing that it forms a (FUS1/MAR1)

Indexed as

ChlamydomonasGerm CellsMembrane FusionCell AdhesionCrystallography, X-RayModels, MolecularProtein BindingSpecies Specificity

Identifiers

PMID42778557
PMCPMC13601591

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.