Evidence map›Paper›PMID 42778519›Full record

ArticleChemMedChem2026

A Blood-Brain Barrier-Permeable Guanylhydrazone Analogue of the ASIC3 Activator GMQ Inhibits Human Glioblastoma Stem Cell Growth In Vitro.

Leonardo Maiorana, Nicoletta Collura, Andrea Gotti, Giulia De Leonardis, Greta Donati, Alice Maiocchi, Luciana Marinelli, Andrea Menegon, Pierfausto Seneci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leonardo MaioranaChemistry Department, Università degli Studi di Milano - La Statale, Milan, Italy.ORCID https://orcid.org/0009-0002-5662-4747
Nicoletta ColluraExperimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID https://orcid.org/0009-0004-1212-143X
Andrea GottiChemistry Department, Università degli Studi di Milano - La Statale, Milan, Italy.ORCID https://orcid.org/0009-0002-3110-7233
Giulia De LeonardisExperimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Greta DonatiDepartment of Pharmacy, Università degli Studi di Napoli Federico Secondo, Naples, Italy.ORCID https://orcid.org/0000-0002-0311-1721
Alice MaiocchiChemistry Department, Università degli Studi di Milano - La Statale, Milan, Italy.ORCID https://orcid.org/0000-0001-5499-4045
Luciana MarinelliDepartment of Pharmacy, Università degli Studi di Napoli Federico Secondo, Naples, Italy.
Andrea MenegonExperimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID https://orcid.org/0000-0002-2396-756X
Pierfausto SeneciChemistry Department, Università degli Studi di Milano - La Statale, Milan, Italy.ORCID https://orcid.org/0000-0001-9709-7344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acid-sensing ion channel 3 (ASIC3) is a neuronal voltage-insensitive Na

Indexed as

Acid Sensing Ion ChannelsAntineoplastic AgentsBlood-Brain BarrierGlioblastomaGuanidinesHydrazonesNeoplastic Stem CellsAnimalsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAcid Sensing Ion ChannelsAntineoplastic AgentsASIC3 protein, humanGuanidinesHydrazonesASIC3 channelsBBB permeabilitycancer stem cell neurospheresglioblastoma multiformeguanyl hydrazones

Identifiers

PMID42778519
PMCPMC13600949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.