Evidence map›Paper›PMID 42778400›Full record

ArticleLife science alliance2026

Fetal growth restriction leads to prolonged nephrogenesis and gene dysregulation in the adult kidney.

Sage Timberline, Rachel K Dailey, Wyatt Johnson, Ayyappa Kumar Sista Kameshwar, Jaya Isaac, Kimberly deRonde, Mark Conaway, Aleksandra Cwiek, Kevin M Bennett, Edwin J Baldelomar and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sage TimberlineDivision of Critical Care, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Rachel K DaileyUniversity of Virginia, Charlottesville, VA, USA.
Wyatt JohnsonUniversity of Virginia, Charlottesville, VA, USA.ORCID https://orcid.org/0009-0000-2558-2615
Ayyappa Kumar Sista KameshwarDepartment of Nutrition, Texas A&M University, College Station, TX, USA.ORCID https://orcid.org/0000-0001-9487-7943
Jaya IsaacDivision of Nephrology, Department of Pediatrics, Children's Hospital at Montefiore, New York, NY, USA.
Kimberly deRondeDivision of Nephrology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Mark ConawayUniversity of Virginia Health System, Charlottesville, VA, USA.
Aleksandra CwiekDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Kevin M BennettMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Edwin J BaldelomarMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Teng LiSchool of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.
Teresa WuSchool of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.
Matthew R HochDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Meredith P SchuhDivision of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Shalini IndugulaDivision of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Yoshinori SekiDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Masako SuzukiDepartment of Nutrition, Texas A&M University, College Station, TX, USA.ORCID https://orcid.org/0000-0003-0605-9225
Kimberly J ReidyDivision of Nephrology, Department of Pediatrics, Children's Hospital at Montefiore, New York, NY, USA.
Jennifer R CharltonDivision of Nephrology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA jrc6n@virginia.edu.ORCID https://orcid.org/0000-0002-2225-535X

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
Investigating the effect of dysregulated vitamin D metabolism on kidney development following preterm birthR01DK136989 · NIDDK · UNIVERSITY OF VIRGINIA · PI Jennifer R Charlton, Kimberly Jean Reidy · 2024 to 2026
$2.1M
Small-Animal 9.4T MRI for Biomedical ResearchS10OD025024 · OD · UNIVERSITY OF VIRGINIA · PI BERR, STUART S. · 2019 to 2019
$2.0M
Bridging the gap of late gestation human nephrogenesis using a non-human primate modelK08DK131259 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI SCHUH, MEREDITH · 2022 to 2024
$574k
The transcriptional, regulatory, and spatially defined changes from mid to late gestation in a non-human primate modelR03DK141897 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI SCHUH, MEREDITH · 2025 to 2025
$241k
NCI NIH HHS P30 CA044579NIDDK NIH HHS K08 DK131259NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK136989NIDDK NIH HHS R03 DK141897NIH HHS S10 OD025024
6 · The paper itself

Abstract

Low birthweight increases chronic kidney disease (CKD) risk. Using a gestational low protein (LP) mouse model, we hypothesized that protein restriction would alter nephrogenesis and adult gene expression. Pregnant CD-1 dams received normal protein (NP) or LP diets. Pups were studied on postnatal days 2-7 to assess the nephron progenitor cell population. Adult mice underwent transdermal GFR measurement and histologic evaluation, bulk RNA sequencing, and cationic-ferritin-enhanced MRI. Nephrogenesis was protracted in LP mice compared with NP mice. Adult LP mice had fewer glomeruli. LP males had lower GFR and more atubular glomeruli without glomerular hypertrophy. LP males demonstrated down-regulated

Indexed as

Fetal Growth RetardationKidneyOrganogenesisAldehyde Dehydrogenase 1 FamilyAnimalsDevelopmental Origins of Health and DiseaseDiet, Protein-RestrictedDisease Models, AnimalFemaleGene Expression Regulation, DevelopmentalGlomerular Filtration RateKidney GlomerulusMaleMiceNephronsPregnancyAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, mouseRetinal Dehydrogenase

Identifiers

PMID42778400
PMCPMC13601832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.