Evidence map›Paper›PMID 42778325›Full record

ArticleBMJ open respiratory research2026

Asthma exacerbation requiring ventilatory support in adults: a 10-year retrospective multicentre cohort study - the ESAVA study.

Nina De Montmollin, Arnaud W Thille, Guillaume Carteaux, Alexis Ferre, Grégoire Jolly, Benoit Painvin, Sébastien Jochmans, Marie Labruyère, Cédric Daubin, Marie Goset and 14 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Nina De MontmollinMédecine Intensive Réanimation, Hôpital Tenon, Paris, France nina.demontmollin@aphp.fr.ORCID http://orcid.org/0000-0001-7496-3350
Arnaud W ThilleMédecine Intensive Réanimation, CHU Poitiers, Poitiers, France.
Guillaume CarteauxMédecine Intensive Réanimation, CHU Henri Mondor, Créteil, France.ORCID http://orcid.org/0000-0003-1175-8821
Alexis FerreMédecine Intensive et Réanimation, CH Versailles, Le Chesnay, France.
Grégoire JollyDepartment of Medical Intensive Care, CHU de Rouen, Rouen, France.
Benoit PainvinMaladie Infectieuse et Réanimation Médicale, CHU de Rennes, Rennes, France.
Sébastien JochmansDépartement de Médecine Intensive, Centre Hospitalier de Melun, Melun, France.
Marie LabruyèreMédecine Intensive et Réanimation, CHU Dijon, Dijon, France.
Cédric DaubinMédecine Intensive et Réanimation, CHU Caen, Caen, Normandy, France.
Marie GosetRéanimation et Soins Continus, CH Roanne, Roanne, France.
Johann AuchabieRéanimation et Soins Continus, CH Cholet, Cholet, France.
Damien ContouRéanimation Polyvalente, CH Argenteuil, Argenteuil, France.
Gael PitonRéanimation Médicale, CHU de Besançon, Besançon, France.
Jerôme DevaquetRéanimation Polyvalente, Hopital Foch, Suresnes, France.
Stanislas LedochowskiMédecine Intensive et Réanimation, CH de Bourgoin-Jallieu, Bourgoin-Jallieu, France.
Thomas RambaudRéanimation Médico-Chirurgicale, Hopital Avicenne, Bobigny, France.
Sarah BenhamidaMédecine Intensive et Réanimation, Groupe Hospitalier Nord-Essonne Hôpital Paris-Saclay, Orsay, France.
Agathe DelboveRéanimation Polyvalente, Centre Hospitalier Bretagne Atlantique, Vannes, France.
Benjamin SztrymfMédecine Intensive et Réanimation, Hopital Antoine-Beclere, Clamart, France.
Mickael LandaisService de Réanimation Médico-Chirurgicale, CH Le Mans, Le Mans, France.
Nathanael LapidusDépartement de Santé Publique, Hopital Saint-Antoine, Paris, France.
Nicolas TerziRéanimation Médicale, CHU Grenoble Alpes, Grenoble, France.
Guillaume VoiriotMédecine Intensive Réanimation, Hôpital Tenon, Paris, France.
REVA Network (Réseau Européen de Recherche en Ventilation)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about the clinical outcomes of patients admitted to the intensive care unit (ICU) for severe asthma exacerbation requiring ventilatory support. RESEARCH QUESTION: Our objectives were (i) to describe the initial presentation, therapeutic management and clinical outcomes of adults admitted to the ICU for asthma exacerbation requiring ventilatory support and (ii) to identify risk factors for a prolonged course and/or fatal outcome. STUDY DESIGN AND

methodsWe conducted a 10-year multicentre (n=21) retrospective study in France. All adult patients with asthma admitted to the ICU for an exacerbation requiring invasive (IMV) and/or non-invasive (NIV) mechanical ventilation were included. The primary endpoint was 'complicated course', a composite criterion of death during the ICU stay and/or the need for IMV for ≥7 days.

resultsFrom 2010 to 2019, 349 patients were included (women 57%, age 54 (40-65) years). Acute respiratory failure was the primary reason for ICU admission. However, 12% of patients were admitted following a cardiorespiratory arrest. Respiratory tract infections were documented in 36% of patients, with

conclusionsExacerbation requiring ventilatory support was associated with a substantial burden in adult patients with asthma. Respiratory infection was the predominant suspected triggering factor. Respiratory tract infections were documented in 36% of patients and were independently associated with a prolonged course and/or fatal outcome in the ICU.

Indexed as

AsthmaRespiration, ArtificialRespiratory InsufficiencyAdultAgedDisease ProgressionFemaleFranceHospital MortalityHumansIntensive Care UnitsMaleMiddle AgedNoninvasive VentilationRespiratory Tract InfectionsRetrospective StudiesAssisted VentilationAsthmaCritical Care

Identifiers

PMID42778325
PMCPMC13629871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.