ArticleVeterinary medicine and science2026
Dihydrotestosterone Promotes Hetian Sheep Dermal Papilla Cell Proliferation by Inhibiting the TGF-β/Smad Signalling Pathway.
Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Hair follicles, as key accessory organs in mammalian skin, are precisely regulated for growth and development influenced by genetic factors, hormones, and the local microenvironment. This study investigated the effect of dihydrotestosterone (DHT) on the proliferation of dermal papilla cells (DPCs) from Xinjiang Hetian sheep and its regulatory relationship with the TGF-β/Smad signalling pathway. DPCs were isolated from the back skin tissue of newborn Hetian sheep by collagenase II digestion, and their characteristics were identified by primary culture, passage, and double immunofluorescence staining with α-SMA and CD133 labelling. CCK-8 and EdU assays were used to evaluate the effect of varying DHT concentrations (0, 1, 10, 100, and 1000 nM) on DPC proliferation. The results showed that with the increased DHT concentration, cell proliferation also increased, and the highest rate was observed at 1000 nM. Furthermore, qPCR analysis revealed that 1000 nM DHT significantly upregulated Smad6 gene expression (p < 0.05), while it inhibited the expression of TGF-β1, TGF-βRII, and Smad5 (p < 0.05). These findings suggest that high DHT concentrations may promote DPC proliferation by inhibiting the TGF-β/Smad signalling pathway. This suggests a critical role of this pathway in regulating hair follicle development and hormone-dependent hair growth, providing evidence for the molecular mechanism of androgen action on dermal papilla cell function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.