Evidence map›Paper›PMID 42777704›Full record

ArticleMolecular cell2026

CaMKII monomers are sufficient for GluN2B binding, co-condensation, and synaptic potentiation.

Carolyn Nicole Brown, C Madison Barker, Carley N Miller, Fan-Yi Chao, Jason Aoto, Steven J Coultrap, K Ulrich Bayer

Abstract read
In one paragraph

Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Carolyn Nicole BrownDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
C Madison BarkerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Carley N MillerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Fan-Yi ChaoDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Jason AotoDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Steven J CoultrapDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
K Ulrich BayerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: ulli.bayer@cuanschutz.edu.

Funding

Medical Scientist Training ProgramT32GM008497 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI WILSON, CARA C. · 1993 to 2022
$15.2M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANE E REUSCH · 2020 to 2026
$10.8M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
CaMKII substrate-selection in opposing forms of synaptic plasticityR01NS081248 · NINDS · UNIVERSITY OF COLORADO DENVER · PI K. Ulrich Bayer · 2013 to 2026
$4.9M
CaMKII nitrosylation in the age-related decline of synaptic plasticityR01AG067713 · NIA · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH · 2020 to 2024
$2.7M
CaMKII in global cerebral ischemia: mechanisms and therapeutic interventionR01NS118786 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2021 to 2025
$1.9M
LTP impairment in Down Syndrome: mechanisms and treatmentsR01NS146039 · NINDS · UNIVERSITY OF COLORADO DENVER · PI K. Ulrich Bayer · 2026 to 2026
$557k
The identification and interrogation of novel intracellular proteins that underlie the distinct nanoscopic architecture of Neurexin-1 and Neurexin-3R21MH140328 · NIMH · UNIVERSITY OF COLORADO DENVER · PI AOTO, JASON · 2025 to 2025
$422k
Impact of stress on heroin seeking and ventral pallidal synapse functionF30DA057053 · NIDA · UNIVERSITY OF COLORADO DENVER · PI MILLER, CARLEY N · 2022 to 2024
$117k
Molecular computation by the CaMKII holoenzymeF31NS129254 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BROWN, CAROLYN NICOLE · 2022 to 2024
$112k
NIA NIH HHS R01 AG067713NIDA NIH HHS F30 DA057053NIDDK NIH HHS P30 DK116073NIGMS NIH HHS T32 GM007635NIGMS NIH HHS T32 GM008497NIMH NIH HHS R21 MH140328NINDS NIH HHS F31 NS129254NINDS NIH HHS R01 NS081248NINDS NIH HHS R01 NS118786NINDS NIH HHS R01 NS146039
6 · The paper itself

Abstract

Cognitive functions require synaptic plasticity, specifically long-term potentiation (LTP). LTP is thought to require Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2Long-Term PotentiationNeuronsReceptors, N-Methyl-D-AspartateSynapsesAnimalsCalciumHippocampusHumansMutationPhosphorylationProtein BindingRatsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2NR2B NMDA receptorReceptors, N-Methyl-D-Aspartateautonomous activityCaMKIIcognitionGluN2Blearning and memoryLTPNMDA receptorsynaptic plasticity

Identifiers

PMID42777704
PMCPMC13681388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.