Effects of monochromatic light on thyroid hormone and endoplasmic reticulum stress-related signaling in broilers.

Miao Chen, Ge Hu, Guifang Cao, Daqing Wang, Chenguang Du, Zixu Wang, Yaoxing Chen, Jing Cao

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Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Miao ChenLaboratory of Anatomy of Domestic Animal, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

Ge HuCollege of Animal Science and Technology, Beijing University of Agriculture, Huilongguan, Beijing, 102206, China.

Guifang CaoAnimal Embryo and Developmental Engineering Key Laboratory of Higher Education, Inner Mongolia Agricultural University, Institutions of Inner Mongolia Autonomous Region, Hohhot, 010011, China.

Daqing WangAnimal Embryo and Developmental Engineering Key Laboratory of Higher Education, Inner Mongolia Agricultural University, Institutions of Inner Mongolia Autonomous Region, Hohhot, 010011, China.

Chenguang DuAnimal Embryo and Developmental Engineering Key Laboratory of Higher Education, Inner Mongolia Agricultural University, Institutions of Inner Mongolia Autonomous Region, Hohhot, 010011, China.

Zixu WangLaboratory of Anatomy of Domestic Animal, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

Yaoxing ChenLaboratory of Anatomy of Domestic Animal, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

Jing CaoLaboratory of Anatomy of Domestic Animal, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. Electronic address: caojing315@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid hormones (TH) are pivotal regulators of poultry growth and development. However, the effects of monochromatic light on thyroid function in broilers remain unclear. Therefore, newly hatched Arbor Acre (AA) broilers were randomly reared under white light (WL, 400-700 nm), red light (RL, 660 nm), green light (GL, 560 nm), and blue light (BL, 480 nm) until 42 days. The results showed that compared with WL, RL reduced thyroid weight and elevated serum free triiodothyronine (FT3) levels, whereas GL produced no significant alterations in thyroid weight or circulating TH levels. In contrast, BL increased thyroid weight and thyroid index and decreased serum triiodothyronine (T3) and FT3 concentrations. Furthermore, thyroid hormone synthesis-related genes were slightly upregulated in RL compared with WL, although these changes were not statistically significant. Conversely, BL downregulated the expression of thyroid hormone synthesis-related genes, including thyroid-stimulating hormone receptor (TshR), thyroid transcription factor 1 (Ttf1), sodium-iodide cotransporter (Nis), and thyroid peroxidase (Tpo), and decreased type 2 deiodinase (Dio2) protein expression. Moreover, endoplasmic reticulum (ER) stress-related markers were slightly decreased in RL but elevated in BL, which activated the PERK-eIF2α-ATF4-CHOP pathway and was associated with oxidative stress and increased Bax expression. These findings suggest that monochromatic light affects thyroid function in broilers, and BL exposure is associated with altered thyroid hormone synthesis and ER stress-related signaling.

Indexed as

broilerendoplasmic reticulum stressmonochromatic lightthyroid hormone

Identifiers

PMID42777370

DOI10.1016/j.psj.2026.107772

PMCPMC13625778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.