ArticlePoultry science2026
Mechanism of tea saponin regulating the Nrf2/HO-1/NQO1 pathway to alleviate Salmonella Enteritidis-induced intestinal pathological injury in chicks.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have demonstrated that Salmonella Enteritidis triggers intestinal pyroptosis and pathological damage in hosts. Tea saponin (Ts) exhibits favorable anti-inflammatory, antioxidant and intestinal barrier-protective activities, whereas its protective role and molecular mechanism against Salmonella Enteritidis-induced intestinal injury in chicks remain poorly elucidated. This study explored the protective effects of Ts on Salmonella Enteritidis-caused intestinal damage in chicks and whether the Nrf2/HO-1/NQO1 signaling pathway mediates its function. A total of 60 7-day-old specific pathogen-free (SPF) chicks were randomly assigned to six groups: control, Salmonella Enteritidis-infected model, low, medium and high-dose Ts intervention groups, and florfenicol positive control group. Except the control group, all chicks received intraperitoneal Salmonella Enteritidis injection for model establishment, followed by 7 consecutive days of corresponding treatments. Diarrhea score, histopathological changes in the ileum and liver, serum liver function parameters (ALT, AST, ALP, TBIL), oxidative stress markers (SOD, GSH‑PX, CAT, MDA), and inflammatory cytokines (TNF‑α, IL‑6, IL‑1β, IL‑10) were measured, and the expression levels of Nrf2/HO‑1/NQO1 pathway components were evaluated at both mRNA and protein levels. Network pharmacology combined with molecular docking further validated the binding relationship between Ts and pathway key proteins. The untreated infected group presented aggravated diarrhea, severe intestinal and hepatic lesions, disordered liver function, oxidative stress and inflammation, along with suppressed Nrf2/HO‑1/NQO1 pathway expression. Ts intervention reversed these damages dose‑dependently, with high‑dose Ts showing the optimal efficacy. In conclusion, Ts mitigates diarrhea, inflammation and visceral pathological injury in Salmonella Enteritidis‑infected chicks, and its effects are associated with activation of the Nrf2/HO‑1/NQO1 pathway, improved antioxidant defense and inhibited inflammatory responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.