Evidence map›Paper›PMID 42777342›Full record

ArticleNeurobiology of aging2026

Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.

Siona Mishra, Corinne Pettigrew, Chidi Ugonna, Nan-Kuei Chen, Jennifer B Frye, Kristian P Doyle, Lee Ryan, Marilyn Albert, Sara Grace Ho, Abhay Moghekar and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Siona MishraSchool of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA.
Corinne PettigrewDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Chidi UgonnaDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
Nan-Kuei ChenDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
Jennifer B FryeDepartment of Immunobiology, University of Arizona, Tucson, AZ, USA.
Kristian P DoyleDepartment of Immunobiology, University of Arizona, Tucson, AZ, USA.
Lee RyanDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Sara Grace HoDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Abhay MoghekarDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Anja SoldanDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Elizabeth R PaitelDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: epaitel1@jhmi.edu.

Funding

Regulatory and Human Study Operations (RHSO) Core CU19AG065169 · NIA · UNIVERSITY OF ARIZONA · PI RYAN, LEE · 2021 to 2025
$59.8M
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3M
NIA NIH HHS T32 AG027668NIA NIH HHS U19 AG065169
6 · The paper itself

Abstract

Chronic inflammation is a common feature of aging and is observed across various age-related neurodegenerative diseases, including Alzheimer's disease (AD). Diffusion magnetic resonance imaging (dMRI) metrics of white matter microstructure are hypothesized to be sensitive to inflammation, though few studies have assessed this relationship in non-clinical populations. This cross-sectional study of 457 dementia-free older adults (M

Indexed as

AgingCRPCytokinesDTIGFAPInflammationNODDI

Identifiers

PMID42777342
PMCPMC13664638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.