Evidence map›Paper›PMID 42777336›Full record

ArticleEuropean journal of radiology2026

Impact of MRI quality on the accuracy of targeted prostate biopsy: A prospective PI-QUAL analysis.

Donald C Wunsch Iii, Omer Tarik Esengur, Rikhil D Makwana, Stephanie A Harmon, Peter L Choyke, Sandeep Gurram, Peter A Pinto, Baris Turkbey

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Article in European journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Donald C Wunsch IiiMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Omer Tarik EsengurMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Rikhil D MakwanaMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stephanie A HarmonMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Peter L ChoykeMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sandeep GurramUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Peter A PintoUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Baris TurkbeyMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: turkbeyi@mail.nih.gov.

Funding

Imaging, image guided biopsy and treatment of prostate cancerZIABC012062 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TÜRKBEY, BARIS · 2021 to 2025
$1.3M
Intramural NIH HHS ZIA BC012062
6 · The paper itself

Abstract

BACKGROUND AND

objectivesMultiparametric MRI (mpMRI) has improved the detection of clinically significant prostate cancer (csPCa). However, the diagnostic utility of mpMRI is heavily dependent on image quality, which is often inconsistent across clinical settings. We investigated the association between mpMRI quality, assessed via the Prostate Imaging Quality (PI-QUAL) score, and the accuracy of MRI-targeted biopsies (TBx) compared to systematic biopsies (SBx).

methodsIn this prospective study of 124 patients, image quality was evaluated for T2-weighted (T2W), diffusion-weighted, and dynamic contrast-enhanced (DCE) sequences using PI-QUAL v2. A biopsy "miss" was defined as a case where SBx detected a higher Gleason grade group than TBx. Statistical analyses, including Mann-Whitney U tests and multivariate logistic regression, were employed to identify predictors of TBx failure.

resultsA total of 15 patients (12.1%) had a TBx "miss." Univariate analysis revealed that suboptimal T2W (p = 0.003) and DCE (p = 0.015) quality were significantly associated with biopsy failure. In a multivariate model, T2W quality remained a clinically potent predictor of inaccuracy (Odds ratio: 12.1, 95% confidence interval: 0.9-164.7, p = 0.06).

conclusionSuboptimal MRI quality, particularly the T2W sequence, is a primary driver of TBx failure. When faced with low PI-QUAL scores, clinicians should remain aware that MRI is less likely to improve detection of cancer compared to SBx. Ideally, low PI-QUAL score MRIs should be repeated to optimize the detection of csPCa.

Indexed as

PI-QUALProstate biopsyProstate cancerprostate MRI

Identifiers

PMID42777336
PMCPMC13641814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.