Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Xuan ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-4276-6464
Abdul-Akim GuseinovSchool of Molecular Biosciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-2796-4323
Laura JenkinsSchool of Molecular Biosciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0003-1382-8547
Jingkai ZhouDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Fabian GossenUniversity of Bonn, PharmaCenter Bonn & Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, 53121 Bonn, Germany.
Pinqi WangDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.ORCID 0009-0007-1160-1206
Zobaer Al MahmudSchool of Molecular Biosciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0003-4048-927X
Yueming LiSchool of Molecular Biosciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Andhika B MahardhikaUniversity of Bonn, PharmaCenter Bonn & Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, 53121 Bonn, Germany.ORCID 0000-0002-0456-1353
Christa E MüllerUniversity of Bonn, PharmaCenter Bonn & Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, 53121 Bonn, Germany.ORCID 0000-0002-0013-6624
Mingye FengDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-3334-9917
Angela J RussellDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.ORCID 0000-0003-3610-9369
Irina G TikhonovaSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK.ORCID 0000-0002-6228-9431
Graeme MilliganSchool of Molecular Biosciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-6946-3519
Cheng ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-9042-4007
Funding
Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammationR35GM128641 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHENG ZHANG · 2018 to 2026
$3.5M
Cryo-electron microscopeS10OD025009 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2018 to 2018
$2.0M
Direct electron detecting (DED) cameraS10OD019995 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2015 to 2015
Allosteric modulators offer opportunities for pathway-selective G protein-coupled receptor (GPCR) signaling, but the mechanisms enabling biased allosteric modulation remain poorly understood. We identify a helix 8-proximate allosteric site in the immune-metabolic receptor GPR84 and define how it achieves G
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mechanism of GPR84 allosteric modulation at a helix 8-proximate site. · full record | OpenQuestion